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工程化 Ag 修饰的氧化石墨烯纳米光热平台，增强抗菌性能，促进感染性伤口愈合。

Engineering Ag-Decorated Graphene Oxide Nano-Photothermal Platforms with Enhanced Antibacterial Properties for Promoting Infectious Wound Healing.

机构信息

Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, 430060, People's Republic of China.

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China.

出版信息

Int J Nanomedicine. 2024 Aug 30;19:8901-8927. doi: 10.2147/IJN.S474536. eCollection 2024.

DOI:10.2147/IJN.S474536
PMID:39233743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11372703/
Abstract

INTRODUCTION

Graphene oxide (GO) nanoparticles have emerged as a compelling photothermal agent (PHTA) in the realm of photothermal antibacterial therapy, owing to their cost-effectiveness, facile synthesis, and remarkable photostability. Nevertheless, the therapeutic efficacy of GO nanoparticles is commonly hindered by their inherent drawback of low photothermal conversion efficiency (PCE).

METHODS

Herein, we engineer the Ag/GO-GelMA platform by growing the Ag on the surface of GO and encapsulating the Ag/GO nanoparticles into the GelMA hydrogels.

RESULTS

The resulting Ag/GO-GelMA platform demonstrates a significantly enhanced PCE (47.6%), surpassing that of pure GO (11.8%) by more than fourfold. As expected, the Ag/GO-GelMA platform, which was designed to integrate the benefits of Ag/GO nanoparticles (high PCE) and hydrogel (slowly releasing Ag to exert an inherent antibacterial effect), has been shown to exhibit exceptional antibacterial efficacy. Furthermore, transcriptome analyses demonstrated that the Ag/GO-GelMA platform could significantly down-regulate pathways linked to inflammation (the MAPK and PI3K-Akt pathways) and had the ability to promote cell migration.

DISCUSSION

Taken together, this study presents the design of a potent photothermal antibacterial platform (Ag/GO-GelMA) aimed at enhancing the healing of infectious wounds. The platform utilizes a handy method to enhance the PCE of GO, thereby making notable progress in the utilization of GO nano-PHTAs.

摘要

简介

氧化石墨烯（GO）纳米粒子因其成本效益高、合成简便和显著的光稳定性，已成为光热抗菌治疗领域有吸引力的光热剂（PHTA）。然而，GO 纳米粒子的治疗效果通常受到其固有低光热转换效率（PCE）的限制。

方法

我们通过在 GO 表面生长 Ag 并将 Ag/GO 纳米颗粒封装到 GelMA 水凝胶中来构建 Ag/GO-GelMA 平台。

结果

所得到的 Ag/GO-GelMA 平台表现出显著增强的 PCE（47.6%），比纯 GO（11.8%）提高了四倍以上。正如预期的那样，Ag/GO-GelMA 平台将 Ag/GO 纳米颗粒（高 PCE）和水凝胶（缓慢释放 Ag 以发挥固有抗菌作用）的优势结合在一起，表现出了出色的抗菌效果。此外，转录组分析表明，Ag/GO-GelMA 平台可以显著下调与炎症相关的途径（MAPK 和 PI3K-Akt 途径），并具有促进细胞迁移的能力。

讨论

总之，本研究提出了一种增强感染性伤口愈合能力的有效光热抗菌平台（Ag/GO-GelMA）的设计。该平台利用一种简便的方法来提高 GO 的 PCE，从而在 GO 纳米 PHTAs 的应用方面取得了显著进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc5/11372703/652009400711/IJN-19-8901-g0010.jpg
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