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Nutrients. 2023 Sep 4;15(17):3854. doi: 10.3390/nu15173854.
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The Potential of as a Source of Biologically Active Compounds-A Review of the Recent Literature and Patents.作为生物活性化合物来源的潜力——对近期文献和专利的综述。
Molecules. 2023 May 9;28(10):3993. doi: 10.3390/molecules28103993.
3
Ginkgolide C attenuates cerebral ischemia/reperfusion-induced inflammatory impairments by suppressing CD40/NF-κB pathway.银杏内酯 C 通过抑制 CD40/NF-κB 通路减轻脑缺血/再灌注诱导的炎症损伤。
J Ethnopharmacol. 2023 Aug 10;312:116537. doi: 10.1016/j.jep.2023.116537. Epub 2023 Apr 23.
4
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta.银杏内酯B通过超氧化物歧化酶1(SOD1)在糖尿病主动脉中的抗氧化作用导致Akt/内皮型一氧化氮合酶(eNOS)信号通路的激活。
Pflugers Arch. 2023 Apr;475(4):453-463. doi: 10.1007/s00424-023-02790-3. Epub 2023 Jan 30.
5
Responses of tree growth, leaf area and physiology to pavement in and .树木生长、叶面积和生理学对[具体地点1]和[具体地点2]路面的响应。
Front Plant Sci. 2022 Dec 1;13:1003266. doi: 10.3389/fpls.2022.1003266. eCollection 2022.
6
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.银杏内酯C通过激活Nrf2/HO-1并阻断NF-κB途径来减缓骨关节炎的进展。
Front Pharmacol. 2022 Oct 28;13:1027553. doi: 10.3389/fphar.2022.1027553. eCollection 2022.
7
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.口服银杏内酯 C 通过维持肠道屏障完整性、抑制炎症反应和调节肠道菌群来减轻 DSS 诱导的结肠炎。
J Agric Food Chem. 2022 Nov 23;70(46):14718-14731. doi: 10.1021/acs.jafc.2c06177. Epub 2022 Nov 14.
8
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.天然产物白果内酯通过抗基质降解和抗氧化活性改善骨关节炎家兔的关节健康。
Front Vet Sci. 2022 Oct 20;9:1034623. doi: 10.3389/fvets.2022.1034623. eCollection 2022.
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Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.靶向血小板激活因子受体(PAF-R):抗血栓和抗动脉粥样硬化的营养素。
Nutrients. 2022 Oct 20;14(20):4414. doi: 10.3390/nu14204414.
10
Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.白果内酯对链脲佐菌素诱导的糖尿病大鼠视网膜氧化应激和炎症的保护作用。
Appl Biochem Biotechnol. 2022 Dec;194(12):6407-6422. doi: 10.1007/s12010-022-04012-5. Epub 2022 Aug 6.

探索银杏内酯和白果内酯在减轻代谢紊乱方面的多方面作用。

Exploring the multifaceted role of ginkgolides and bilobalide from in mitigating metabolic disorders.

作者信息

Kim Hayoon, Kang Sumin, Go Gwang-Woong

机构信息

Department of Food and Nutrition, Hanyang University, Seoul, 04763 Republic of Korea.

出版信息

Food Sci Biotechnol. 2024 Jul 10;33(13):2903-2917. doi: 10.1007/s10068-024-01656-3. eCollection 2024 Oct.

DOI:10.1007/s10068-024-01656-3
PMID:39234277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11370650/
Abstract

The ancient Ginkgo biloba tree grows across various regions, with distinctive leaves emitting a unique fragrance. Its extract contains flavonoids, organic acids, and terpenoids. Ginkgolide and bilobalide, which are leaf extracts, offer diverse pharmaceutical benefits, including antioxidant, anti-inflammatory, and neuroprotective properties. The antioxidant and anti-inflammatory properties of these compounds are crucial for mitigating neurodegeneration, particularly in diseases such as Alzheimer's disease. Additionally, their effectiveness in countering oxidative stress and inflammation highlights their potential to prevent cardiovascular ailments. This study also suggests that these compounds have a promising impact on lipid metabolism, suggesting their significance in addressing obesity-related metabolic disorders. In conclusion, ginkgolides and bilobalide exhibit promising effects in sustaining the integrity of the nervous and endocrine systems, along with the modulation of lipid metabolism. The diverse health benefits suggest that these compounds could serve as promising therapeutic interventions for various conditions, including neurological, cardiovascular, and metabolic diseases.

摘要

古老的银杏树生长在各个地区,其独特的叶子散发着独特的香气。它的提取物含有黄酮类化合物、有机酸和萜类化合物。银杏内酯和白果内酯作为叶子提取物,具有多种药用功效,包括抗氧化、抗炎和神经保护特性。这些化合物的抗氧化和抗炎特性对于减轻神经退行性变至关重要,尤其是在阿尔茨海默病等疾病中。此外,它们在对抗氧化应激和炎症方面的有效性凸显了其预防心血管疾病的潜力。这项研究还表明,这些化合物对脂质代谢有积极影响,表明它们在解决与肥胖相关的代谢紊乱方面具有重要意义。总之,银杏内酯和白果内酯在维持神经和内分泌系统的完整性以及调节脂质代谢方面显示出有前景的效果。多种健康益处表明,这些化合物可作为针对各种病症(包括神经、心血管和代谢疾病)的有前景的治疗干预措施。