Do Thanh-Hung, Duong Thuc-Huy, Ho Minh-Truong-Tho, Pham Duc-Dung, Nguyen Thu-Hoang-Mai, Aonbangkhen Chanat, Sichaem Jirapast, Nguyen Chuong Hoang, Vo Thi-Phi-Giao, Nguyen Ngoc-Hong, Tran Thi-Minh-Dinh
Laboratory of Biophysics, Institute for Advanced Study in Technology, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2024 Sep 5:1-7. doi: 10.1080/14786419.2024.2398736.
Lichen is well-known for its various purposes. However, understanding the chemical composition and antimicrobial characteristics of cf. remains insufficient. In this study, a new compound, graphinone A (), together with three known compounds, handelone (), 4--methylhiascic acid (), and ethyl orsellinate () were isolated and structurally elucidated. Their chemical structures were established using comprehensive spectroscopic data (1D- and 2D-NMR and HRESIMS). Compounds - were tested for antimicrobial activity against methicillin-resistant (MRSA) and evaluated for the alpha-glucosidase inhibition.
地衣因其多种用途而闻名。然而,对cf.的化学成分和抗菌特性的了解仍然不足。在本研究中,分离并鉴定了一种新化合物石墨酮A()以及三种已知化合物汉德洛酮()、4-甲基海松酸()和苔色酸乙酯()的结构。利用综合光谱数据(一维和二维核磁共振以及高分辨率电喷雾电离质谱)确定了它们的化学结构。对化合物-进行了抗耐甲氧西林金黄色葡萄球菌(MRSA)的抗菌活性测试,并评估了其对α-葡萄糖苷酶的抑制作用。