Gao Dandan, Zhang Heng, Sun Wanjun, Wang Huaqing, Wang Hui
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Oncology, Tianjin Union Medical Center, Nankai University, Tianjin, China.
DNA Cell Biol. 2024 Nov;43(11):537-548. doi: 10.1089/dna.2024.0105. Epub 2024 Sep 5.
Radiation-induced intestinal injury is one of the most common intestinal complications caused by pelvic and abdominal tumor radiotherapy, severely impacting patients' quality of life. Ionizing radiation, while killing tumor cells, inevitably damages healthy tissue. Radiation-induced enteropathy results from radiation therapy-induced intestinal tissue damage and inflammatory responses. This damage involves various complex molecular mechanisms, including cell apoptosis, oxidative stress, release of inflammatory mediators, disruption of immune responses, and imbalance of intestinal microbiota. A thorough understanding of these molecular mechanisms is crucial for developing effective prevention and treatment strategies.
放射性肠损伤是盆腔和腹部肿瘤放疗引起的最常见的肠道并发症之一，严重影响患者的生活质量。电离辐射在杀死肿瘤细胞的同时，不可避免地会损害健康组织。放射性肠病是由放射治疗引起的肠道组织损伤和炎症反应所致。这种损伤涉及各种复杂的分子机制，包括细胞凋亡、氧化应激、炎症介质的释放、免疫反应的破坏以及肠道微生物群的失衡。深入了解这些分子机制对于制定有效的预防和治疗策略至关重要。
