Department of Reproductive Medicine and Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576104.
Department of Neurology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576104.
J Assist Reprod Genet. 2024 Oct;41(10):2667-2680. doi: 10.1007/s10815-024-03231-5. Epub 2024 Sep 5.
The purpose of this study was to determine the effects of intrauterine infusion of autologous blood cell derivative (ABCD) on endometrial thickness and pregnancy outcomes in a group of patients who underwent IVF with recurrent implantation failure (RIF) and who had either a normal endometrium or thin endometrium.
This retrospective study included 63 patients who experienced RIF at the Department of Reproductive Medicine and Surgery, KMC, Manipal, between January 2021 and March 2024 and who received three doses of intrauterine ABCD infusion to prepare the endometrium for frozen embryo transfer (FET).
We enrolled 63 RIF patients, 30 with a normal endometrium (NEM) and 33 with a thin endometrium (TEM). The endometrial thickness (EMT) significantly increased across all the groups. After 3 cycles of intrauterine ABCD infusion, the mean increases in EMT in the NEM and TEM groups were 0.77 mm and 1.36 mm, respectively, which were statistically significant. Among the 62 completed FET cycles, 40.3% were positive for beta-hCG. The clinical pregnancy rate was 33.8% (40% in the NEM group, 28.1% in the TEM group), and the live birth rate was 24.2% (30% in the NEM group, 18.8% in the TEM group). A total of 9.7% of pregnancies had spontaneous miscarriages. Moreover, the EMT did not differ between the pregnant and nonpregnant groups.
Intrauterine ABCD infusion improves the pregnancy outcomes of patients with RIF, regardless of the EMT. The results of this study revealed that endometrial receptivity improved significantly along with the EMT.
本研究旨在确定宫内输注自体血细胞衍生物（ABCD）对接受反复着床失败（RIF）的体外受精（IVF）且子宫内膜正常或薄的患者的子宫内膜厚度和妊娠结局的影响。
本回顾性研究纳入了 2021 年 1 月至 2024 年 3 月在 Manipal KMC 生殖医学与外科系接受三次宫内 ABCD 输注以准备冷冻胚胎移植（FET）的子宫内膜的 63 名 RIF 患者。
我们共纳入了 63 名 RIF 患者，其中 30 名患者的子宫内膜正常（NEM），33 名患者的子宫内膜薄（TEM）。所有组的子宫内膜厚度（EMT）均显著增加。在宫内 ABCD 输注 3 个周期后，NEM 和 TEM 组 EMT 的平均增加量分别为 0.77mm 和 1.36mm，均具有统计学意义。在 62 个完成的 FET 周期中，有 40.3%的β-hCG 检测呈阳性。临床妊娠率为 33.8%（NEM 组为 40%，TEM 组为 28.1%），活产率为 24.2%（NEM 组为 30%，TEM 组为 18.8%）。总共有 9.7%的妊娠发生自然流产。此外，妊娠组和非妊娠组的 EMT 无差异。
宫内 ABCD 输注可改善 RIF 患者的妊娠结局，与 EMT 无关。本研究结果表明，子宫内膜容受性随着 EMT 的改善而显著提高。
