Maurer A H, Siegel J A, Blasius K M, Deneberg B S, Spann J F, Malmud L S
Radiology. 1985 Jul;156(1):197-202. doi: 10.1148/radiology.156.1.3923553.
Using attenuation-corrected radionuclide volumes and arm-cuff peak systolic pressures, we established the mean value for the ratio of left ventricular (LV) peak systolic pressure/end systolic volume at rest for 15 healthy persons. In 43 patients with coronary disease, this ratio was more sensitive as an indicator of abnormal LV function and for predicting coronary artery disease than the resting ejection fraction. The slope of an end systolic pressure-volume line was also calculated from data obtained under three loading conditions: at rest, during isometric handgrip testing, and after the sublingual administration of nitroglycerin. The sensitivity of the slope for predicting the presence of coronary artery disease was not significantly different from the resting peak systolic pressure/end systolic volume ratio but was helpful in identifying patients with coronary artery disease. These results represent an improvement over previous radionuclide pressure-volume measurements that have not used attenuation correction and show the need for accurate, nongeometric measurements of the LV end systolic volume.
利用经衰减校正的放射性核素容积和臂袖式收缩压峰值，我们确定了15名健康人的静息状态下左心室（LV）收缩压峰值/舒张末期容积比值的平均值。在43例冠心病患者中，作为左心室功能异常的指标以及预测冠状动脉疾病，该比值比静息射血分数更为敏感。舒张末期压力-容积线的斜率也是根据在三种负荷条件下获得的数据计算得出的：静息状态、等长握力试验期间以及舌下含服硝酸甘油后。该斜率预测冠状动脉疾病存在的敏感性与静息收缩压峰值/舒张末期容积比值无显著差异，但有助于识别冠心病患者。这些结果相较于之前未采用衰减校正的放射性核素压力-容积测量有所改进，并表明需要对左心室舒张末期容积进行准确的、非几何学测量。
