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KLF5在肠道微生物群与肺腺癌中的作用：揭示程序性细胞死亡途径及预后生物标志物

The role of KLF5 in gut microbiota and lung adenocarcinoma: unveiling programmed cell death pathways and prognostic biomarkers.

作者信息

Fang Qingliang, Xu Meijun, Yao Wenyi, Wu Ruixin, Han Ruiqin, Kawakita Satoru, Shen Aidan, Guan Sisi, Zhang Jiliang, Sun Xiuqiao, Zhou Mingxi, Li Ning, Sun Qiaoli, Dong Chang-Sheng

机构信息

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No.725, Wanping Rd, Shanghai, 200032, China.

Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No.725, Wanping Rd, Shanghai, 200032, China.

出版信息

Discov Oncol. 2024 Sep 5;15(1):408. doi: 10.1007/s12672-024-01257-w.

DOI:10.1007/s12672-024-01257-w
PMID:39235679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377401/
Abstract

Lung adenocarcinoma (LUAD) is the most important subtype of lung cancer. It is well known that the gut microbiome plays an important role in the pathophysiology of various diseases, including cancer, but little research has been done on the intestinal microbiome associated with LUAD. Utilizing bioinformatics tools and data analysis, we identified novel potential prognostic biomarkers for LUAD. To integrate differentially expressed genes and clinical significance modules, we used a weighted correlation network analysis system. According to the Peryton database and the gutMGene database, the composition and structure of gut microbiota in LUAD patients differed from those in healthy individuals. LUAD was associated with 150 gut microbiota and 767 gut microbiota targets, with Krüppel-like factor 5 (KLF5) being the most closely related. KLF5 was associated with immune status and correlated well with the prognosis of LUAD patients. The identification of KLF5 as a potential prognostic biomarker suggests its utility in improving risk stratification and guiding personalized treatment strategies for LUAD patients. Altogether, KLF5 could be a potential prognostic biomarker in LUAD.

摘要

肺腺癌（LUAD）是肺癌最重要的亚型。众所周知，肠道微生物群在包括癌症在内的各种疾病的病理生理学中起着重要作用，但关于与LUAD相关的肠道微生物群的研究却很少。利用生物信息学工具和数据分析，我们鉴定了LUAD新的潜在预后生物标志物。为了整合差异表达基因和临床意义模块，我们使用了加权相关网络分析系统。根据Peryton数据库和gutMGene数据库，LUAD患者肠道微生物群的组成和结构与健康个体不同。LUAD与150种肠道微生物群和767个肠道微生物群靶点相关，其中Krüppel样因子5（KLF5）关系最为密切。KLF5与免疫状态相关，与LUAD患者的预后密切相关。将KLF5鉴定为潜在的预后生物标志物表明其在改善LUAD患者的风险分层和指导个性化治疗策略方面的效用。总之，KLF5可能是LUAD的潜在预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/edaa7b796a8c/12672_2024_1257_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/01d1814f1daa/12672_2024_1257_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/3af0016d4257/12672_2024_1257_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/47b24faa0e65/12672_2024_1257_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/eec2b94f5582/12672_2024_1257_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/3bec17606997/12672_2024_1257_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/7d3f838381a3/12672_2024_1257_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/edaa7b796a8c/12672_2024_1257_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/01d1814f1daa/12672_2024_1257_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/5cf484758b8f/12672_2024_1257_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/3af0016d4257/12672_2024_1257_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/47b24faa0e65/12672_2024_1257_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/eec2b94f5582/12672_2024_1257_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/3bec17606997/12672_2024_1257_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/7d3f838381a3/12672_2024_1257_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7daa/11377401/edaa7b796a8c/12672_2024_1257_Fig8_HTML.jpg

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