Department of Medicine, Thomas Jefferson University Hospital, 901 Walnut St, Philadelphia, PA, 19107, USA.
Chicago Internal Medicine Practice and Research, 101 Madison St Suite 300, Oak Park, IL, 60302, USA.
Curr Gastroenterol Rep. 2024 Dec;26(12):315-322. doi: 10.1007/s11894-024-00945-5. Epub 2024 Sep 5.
The prevalence of IBD in older adults is rapidly growing. Older adults with IBD are underrepresented in research and clinical trials and yet at great risk for adverse events. Therefore, understanding advanced aged associated constructs in older adults can be critical to improving the management of older adults with IBD.
In this review, we present recent studies on frailty in IBD. We identify 4 major themes in the literature: studies that describe frailty in patients with IBD, studies that report on consequences of frailty, studies of frailty as a risk stratification modality, and studies of frailty as an exposure and outcome. In reviewing the literature, we discuss the heterogeneity that exists and outline future directions to ensure appropriate applications for frailty in the field of IBD.
老年人中炎症性肠病的患病率正在迅速增长。患有炎症性肠病的老年人在研究和临床试验中代表性不足，但他们发生不良事件的风险很大。因此，了解老年人中与高龄相关的结构因素对于改善老年人炎症性肠病的管理至关重要。
在这篇综述中，我们介绍了炎症性肠病衰弱方面的最新研究。我们在文献中确定了 4 个主要主题：描述炎症性肠病患者衰弱的研究、报告衰弱后果的研究、将衰弱作为风险分层方式的研究，以及将衰弱作为暴露和结果因素的研究。在回顾文献时，我们讨论了存在的异质性，并概述了未来的方向，以确保在炎症性肠病领域中对衰弱进行适当的应用。
