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UPR-免疫轴作为生理食物评价系统，在感知低质量食物时促进厌恶行为。

UPR-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.

机构信息

Southwest United Graduate School,Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China.

出版信息

Elife. 2024 Sep 5;13:RP94181. doi: 10.7554/eLife.94181.

DOI:10.7554/eLife.94181
PMID:39235964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377039/
Abstract

To survive in challenging environments, animals must develop a system to assess food quality and adjust their feeding behavior accordingly. However, the mechanisms that regulate this chronic physiological food evaluation system, which monitors specific nutrients from ingested food and influences food-response behavior, are still not fully understood. Here, we established a low-quality food evaluation assay system and found that heat-killed (HK- a low-sugar food, triggers cellular UPR and immune response. This encourages animals to avoid low-quality food. The physiological system for evaluating low-quality food depends on the UPR (IRE-1/XBP-1) - Innate immunity (PMK-1/p38 MAPK) axis, particularly its neuronal function, which subsequently regulates feeding behaviors. Moreover, animals can adapt to a low-quality food environment through sugar supplementation, which inhibits the UPR -PMK-1 regulated stress response by increasing vitamin C biosynthesis. This study reveals the role of the cellular stress response pathway as physiological food evaluation system for assessing nutritional deficiencies in food, thereby enhancing survival in natural environments.

摘要

为了在充满挑战的环境中生存，动物必须发展出一种系统来评估食物质量，并相应地调整它们的进食行为。然而，调节这种从摄入的食物中监测特定营养物质并影响食物反应行为的慢性生理食物评估系统的机制仍未完全清楚。在这里，我们建立了一个低质量食物评估检测系统，发现热杀死的（HK-一种低糖食物，会引发细胞未折叠蛋白反应和免疫反应。这促使动物避免低质量的食物。评估低质量食物的生理系统依赖于未折叠蛋白反应（IRE-1/XBP-1）-先天免疫（PMK-1/p38 MAPK）轴，特别是其神经元功能，随后调节进食行为。此外，动物可以通过补充糖来适应低质量的食物环境，通过增加维生素 C 生物合成来抑制未折叠蛋白反应-PMK-1 调节的应激反应。这项研究揭示了细胞应激反应途径作为生理食物评估系统的作用，用于评估食物中的营养缺乏，从而提高在自然环境中的生存能力。

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