Qin Kai-Xuan, Su Yun-Shu, Zhu Ming-Qiang, Li Chong
Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China.
Chembiochem. 2024 Dec 2;25(23):e202400326. doi: 10.1002/cbic.202400326. Epub 2024 Nov 6.
Photochromic diarylethene has attracted broad research interest in optical applications owing to its excellent fatigue resistance and unique bistability. Photoswitchable fluorescent diarylethene become a powerful molecular tool for fluorescence imaging recently. Herein, the recent progress on photoswitchable fluorescent diarylethenes in bioimaging is reviewed. We summarize the structures and properties of diarylethene fluorescence probes and emphatically introduce their applications in bioimaging as well as super-resolution imaging. Additionally, we highlight the current challenges in practical applications and provide the prospects of the future development directions of photoswitchable fluorescent diarylethene in the field of bioimaging. This comprehensive review aims to stimulate further research into higher-performance photoswitchable fluorescent molecules and advance their progress in biological application.
光致变色二芳基乙烯因其出色的抗疲劳性和独特的双稳态性，在光学应用领域引起了广泛的研究兴趣。可光开关荧光二芳基乙烯最近成为荧光成像的强大分子工具。在此，综述了可光开关荧光二芳基乙烯在生物成像方面的最新进展。我们总结了二芳基乙烯荧光探针的结构和性质，并着重介绍了它们在生物成像以及超分辨率成像中的应用。此外，我们强调了实际应用中当前面临的挑战，并展望了可光开关荧光二芳基乙烯在生物成像领域未来的发展方向。这篇全面的综述旨在激发对高性能可光开关荧光分子的进一步研究，并推动其在生物应用中的进展。
