School of Chemistry and Chemical Engineering, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Industry-Education-Research Institute of Advanced Materials and Technology for Integrated Circuits, Anhui University, Hefei 230601, P. R. China.
ACS Appl Bio Mater. 2024 Sep 16;7(9):6306-6312. doi: 10.1021/acsabm.4c01024. Epub 2024 Sep 5.
Structure engineering is of great importance to enhance the carrier separation efficiency of multiphoton absorption (MPA) materials for near-infrared (NIR) light-driven reactive oxygen species (ROS) generation. In this study, the MPA-responsive potassium/cyano group-functionalized graphitic carbon nitride was investigated, demonstrating charge redistribution and improved carrier separation efficiency by density functional theory calculations and experimental results. With various types of boosted ROS generation under UV-vis or NIR-II light irradiation, the potassium/cyano group-functionalized graphitic carbon nitride could achieve efficient multiphoton photodynamic therapy after reducing the particle size. This study developed a simple strategy to manipulate charge distribution for booting NIR light-activated ROS generation in efficient multiphoton photodynamic therapy.
结构工程对于提高多光子吸收（MPA）材料的载体分离效率至关重要，因为这种材料可以用于近红外（NIR）光驱动活性氧（ROS）的产生。在这项研究中，研究了 MPA 响应的钾/氰基功能化石墨相氮化碳，通过密度泛函理论计算和实验结果表明，其通过电荷再分布提高了载流子分离效率。在紫外可见或近红外二区光照射下，各种类型的 ROS 得到了增强，钾/氰基功能化石墨相氮化碳通过减小粒径实现了高效的多光子光动力治疗。本研究开发了一种简单的策略来操纵电荷分布，以提高近红外光激活 ROS 生成的效率，从而实现高效的多光子光动力治疗。
