Zhan Mengke, Zhou Danyang, Lei Lijing, Zhu Jinhua, Khan Md Zaved H, Liu Xiuhua, Ma Fanyi
College of Chemistry and Molecular Sciences, Henan International Joint Laboratory of Medicinal Plants Utilization, Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng 475004, China.
College of Chemistry and Molecular Sciences, Henan International Joint Laboratory of Medicinal Plants Utilization, Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng 475004, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114200. doi: 10.1016/j.colsurfb.2024.114200. Epub 2024 Sep 2.
A water stable cyclodextrin MOF (Cu-SD) was synthesized with γ-cyclodextrin derivative as organic ligand and Cu as metal center to co-crystallizely load glycyrrhizic acid (GL) and glycyrrhetinic acid (GA). Cu-SD has a high drug loading capacity for GL (499.91 μg/mg) and GA (112.37 μg/mg), and the drug-loaded materials had a controlled release in different meadiums. In addition, Cu-SD and its drug loaded materials demonstrated better inhibiting α-glucosidase activity than the control drug acarbose. Furthermore, Cu-SD presented excellent antibacterial activity, and the antibacterial activity was significantly enhanced after GA and GL being encapsulated by Cu-SD. Moreover, both free and drug-loaded materials had good anti-inflammatory activities, and the anti-inflammatory effects of GL@Cu-SD and GA@Cu-SD were superior to those of their corresponding free drugs. Cu-SD, GL@Cu-SD and GA@Cu-SD demonstrated good biocompatibility and were applied to treat the wounds of diabetic rats. The experimental results showed that GL@Cu-SD and GA@Cu-SD had good promoting effects on the recovery of chronic diabetic wounds by suppressing wound inflammation.
以γ-环糊精衍生物为有机配体、铜为金属中心，合成了一种水稳定的环糊精金属有机框架材料（Cu-SD），用于共结晶负载甘草酸（GL）和甘草次酸（GA）。Cu-SD对GL（499.91μg/mg）和GA（112.37μg/mg）具有较高的载药能力，且载药材料在不同介质中具有缓释性能。此外，Cu-SD及其载药材料对α-葡萄糖苷酶活性的抑制作用优于对照药物阿卡波糖。此外，Cu-SD具有优异的抗菌活性，GA和GL被Cu-SD包封后，抗菌活性显著增强。而且，游离态和载药材料均具有良好的抗炎活性，GL@Cu-SD和GA@Cu-SD的抗炎效果优于其相应的游离药物。Cu-SD、GL@Cu-SD和GA@Cu-SD表现出良好的生物相容性，并应用于治疗糖尿病大鼠的伤口。实验结果表明，GL@Cu-SD和GA@Cu-SD通过抑制伤口炎症对慢性糖尿病伤口的愈合具有良好的促进作用。
