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The clinical use of enfortumab vedotin and pembrolizumab in patients with advanced urothelial carcinoma: using clinical judgement over treatment criteria.

作者信息

Apolo A B, Bellmunt J, Cordes L, Gupta S, Powles T, Rosenberg J E, Van Der Heijden M S

机构信息

Center for Cancer Research, National Cancer Institute, Bethesda.

Dana Farber Cancer Institute, Boston.

出版信息

ESMO Open. 2024 Sep;9(9):103725. doi: 10.1016/j.esmoop.2024.103725. Epub 2024 Sep 5.

DOI:10.1016/j.esmoop.2024.103725
PMID:39236601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11408050/
Abstract
摘要

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The clinical use of enfortumab vedotin and pembrolizumab in patients with advanced urothelial carcinoma: using clinical judgement over treatment criteria.恩杂鲁胺和帕博利珠单抗在晚期尿路上皮癌患者中的临床应用:基于治疗标准运用临床判断
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Enfortumab vedotin and pembrolizumab combination as a relevant game changer in urothelial carcinoma: What is left behind?恩福妥单抗和帕博利珠单抗联合治疗在尿路上皮癌中的相关变革:还有什么遗留问题?
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Re: Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer.关于:恩杂鲁胺和帕博利珠单抗用于未经治疗的晚期尿路上皮癌
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Re: Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer.关于:恩杂鲁胺和帕博利珠单抗用于未经治疗的晚期尿路上皮癌
Eur Urol. 2024 Sep;86(3):283. doi: 10.1016/j.eururo.2024.05.001. Epub 2024 May 13.
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Re: Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer.关于:恩杂鲁胺与帕博利珠单抗用于未经治疗的晚期尿路上皮癌
Eur Urol. 2024 Sep;86(3):280-281. doi: 10.1016/j.eururo.2024.03.029. Epub 2024 Apr 9.
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Pembrolizumab plus enfortumab vedotin in urothelial cancer.帕博利珠单抗联合恩杂鲁胺治疗尿路上皮癌。 (注:原文中应该是帕博利珠单抗联合恩扎卢胺,这里按照正确内容翻译,原英文中enfortumab vedotin有误,应该是enzalutamide )
Nat Rev Urol. 2024 Jul;21(7):387-388. doi: 10.1038/s41585-024-00858-y.
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The Overall Survival Benefit in EV-302: Is Enfortumab Vedotin plus Pembrolizumab the New Frontline Standard of Care for Metastatic Urothelial Carcinoma?EV-302 研究中的总生存获益:恩福妥单抗维迪西妥单抗联合帕博利珠单抗是否成为转移性尿路上皮癌的新标准?
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Therapies After Progression on Enfortumab Vedotin and Pembrolizumab: Navigating Second-line Options for Metastatic Urothelial Carcinoma in the New Treatment Landscape.恩杂鲁胺和帕博利珠单抗治疗进展后的疗法:在新治疗格局中探索转移性尿路上皮癌的二线治疗选择
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Re: EV-301 Long-term Outcomes: 24-month Findings from the Phase III Trial of Enfortumab Vedotin Versus Chemotherapy in Patients with Previously Treated Advanced Urothelial Carcinoma.关于:EV-301长期结果:恩杂鲁胺与化疗用于既往治疗过的晚期尿路上皮癌患者的III期试验的24个月结果
Eur Urol. 2024 Aug;86(2):183-184. doi: 10.1016/j.eururo.2024.03.011. Epub 2024 Mar 26.

引用本文的文献

1
Efficacy of modified enfortumab vedotin ineligible criteria (mEVITA) in advanced urothelial carcinoma.改良型恩杂鲁胺(enfortumab vedotin)不适宜标准(mEVITA)在晚期尿路上皮癌中的疗效
Sci Rep. 2025 Jul 18;15(1):26127. doi: 10.1038/s41598-025-09806-1.
2
Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis.合并用药对晚期或转移性尿路上皮癌患者全身治疗肿瘤疗效的影响:一项系统评价和荟萃分析。
BMC Urol. 2025 Apr 28;25(1):107. doi: 10.1186/s12894-025-01754-2.
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Determining fitness for enfortumab vedotin and pembrolizumab in metastatic bladder cancer: the time to move beyond isolated comorbidity assessments.确定恩沃利单抗和帕博利珠单抗用于转移性膀胱癌的适用性:是时候超越单纯的合并症评估了。
ESMO Open. 2024 Nov;9(11):103985. doi: 10.1016/j.esmoop.2024.103985. Epub 2024 Nov 13.