Lin Jingwen, Liu Jiaming, Liu Zhexuan, Fu Wu, Cai Hongfu
Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China; The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
College of Stomatology, Xinjiang Medical University, Xinjiang, People's Republic of China.
J Stomatol Oral Maxillofac Surg. 2025 Feb;126(1):102031. doi: 10.1016/j.jormas.2024.102031. Epub 2024 Sep 3.
Third molar surgery often results in postoperative complications such as pain, trismus, and facial swelling due to surgical trauma. Concentrated Growth Factor (CGF), a third-generation platelet concentrate, is believed to enhance wound healing due to its rich content of growth factors and fibrin.
This systematic review followed PRISMA guidelines and included a search of PubMed, Embase, and Cochrane Library up to April 18, 2024. Randomized controlled trials involving CGF-treated versus non-CGF-treated patients undergoing third molar surgery were included. Risk of bias was assessed using the Cochrane Collaboration RoB 2.0.
Ten studies were included. CGF significantly improved wound healing, with enhanced soft and hard tissue recovery. Pain relief was notable on postoperative days 3 and 7, although results varied. CGF reduced facial swelling significantly on days 3 and 7 post-surgery. Trismus outcomes were mixed, with some studies reporting significant alleviation and others showing no advantage. CGF showed potential in reducing dry socket incidence, though evidence was not robust.
CGF appears to promote wound healing and reduce postoperative complications such as pain and swelling after third molar surgery. However, its effects on trismus and dry socket incidence remain controversial. Further research with standardized measures is needed to confirm these findings.
由于手术创伤，智齿拔除术术后常出现疼痛、张口受限和面部肿胀等并发症。浓缩生长因子（CGF）是第三代血小板浓缩物，因其富含生长因子和纤维蛋白，被认为可促进伤口愈合。
本系统评价遵循PRISMA指南，检索了截至2024年4月18日的PubMed、Embase和Cochrane图书馆。纳入了比较接受CGF治疗与未接受CGF治疗的智齿拔除术患者的随机对照试验。使用Cochrane协作网的RoB 2.0评估偏倚风险。
纳入10项研究。CGF显著改善伤口愈合，促进软组织和硬组织恢复。术后第3天和第7天疼痛缓解明显，尽管结果有所不同。CGF在术后第3天和第7天显著减轻面部肿胀。张口受限的结果不一，一些研究报告有显著缓解，而另一些研究则显示无优势。CGF在降低干槽症发生率方面显示出潜力，但证据并不充分。
CGF似乎能促进智齿拔除术后的伤口愈合，并减少疼痛和肿胀等术后并发症。然而，其对张口受限和干槽症发生率的影响仍存在争议。需要进一步开展采用标准化测量方法的研究来证实这些发现。
