Department of Neurosurgery, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch), Zhejiang, China.
Department of Neurosurgery, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch), Zhejiang, China.
Cell Signal. 2024 Dec;124:111380. doi: 10.1016/j.cellsig.2024.111380. Epub 2024 Sep 3.
Gliomas, the most prevalent malignant brain tumors in the central nervous system, are marked by rapid growth, high recurrence rates, and poor prognosis. Glioblastoma (GBM) stands out as the most aggressive subtype, characterized by significant heterogeneity. The etiology of gliomas remains elusive. RNA modifications, particularly reversible methylation, play a crucial role in regulating transcription and translation throughout the RNA lifecycle. Increasing evidence highlights the prevalence of RNA methylation in primary central nervous system malignancies, underscoring its pivotal role in glioma pathogenesis. This review focuses on recent findings regarding changes in RNA methylation expression and their effects on glioma development and progression, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and N7-methylguanosine (m7G). Given the extensive roles of RNA methylation in gliomas, the potential of RNA methylation-related regulators as prognostic markers and therapeutic targets was also explored, aiming to enhance clinical management and improve patient outcomes.
神经胶质瘤是中枢神经系统中最常见的恶性脑肿瘤，其生长迅速、复发率高、预后差。胶质母细胞瘤（GBM）是最具侵袭性的亚型，具有显著的异质性。神经胶质瘤的病因仍然难以捉摸。RNA 修饰，特别是可逆甲基化，在调节整个 RNA 生命周期的转录和翻译中起着关键作用。越来越多的证据强调了 RNA 甲基化在原发性中枢神经系统恶性肿瘤中的普遍性，突出了其在神经胶质瘤发病机制中的关键作用。本综述重点介绍了关于 RNA 甲基化表达变化及其对神经胶质瘤发生和发展的影响的最新发现，包括 N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）、N1-甲基腺苷（m1A）和 N7-甲基鸟苷（m7G）。鉴于 RNA 甲基化在神经胶质瘤中的广泛作用，还探讨了 RNA 甲基化相关调节剂作为预后标志物和治疗靶点的潜力，旨在增强临床管理并改善患者预后。
