China Waterborne Transport Research Institute, Beijing 100088, China; School of Public Health (Shenzhen), Shenzhen Campus of SunYat-sen University, Shenzhen, 518107, China.
State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Food Chem Toxicol. 2024 Nov;193:114982. doi: 10.1016/j.fct.2024.114982. Epub 2024 Sep 3.
Perchlorate and chlorate are recognized as ubiquitously inorganic pollutants inenvrionment owing to their high solubility in water and resistance to degradation. Previous studies have confirmed the potential adverse effects of perchlorate and chlorate on human thyroid function, along with implications for fetal growth and development. The fetus grows and develops pregnant women's womb and absorbs nutrients from her body. However, there is still limited information on prenatal exposure to perchlorate and chlorate and the related health risks, especially in China. In this study, a total of 430 serum specimens obtained from pregnant females residing in Southern China were analyzed to ascertain the levels of perchlorate and chlorate, and explore the relationship between perchlorate and chlorate and thyroid function by linear regression, WQS, and QGC. The measured serum levels of perchlorate and chlorate were comparatively elevated, demonstrating median values of 0.693 μg/L and 1.36 μg/L, respectively. The estimated exposure dose of perchlorate in 19.7% of pregnant women exceeded the USEPA reference dose, indicating potential health risks. Although no significant association was found between serum perchlorate and thyroid hormone levels, the exposure to perchlorate for pregnant women in Southern China is cause for concern given their sensitivity to chemicals during pregnancy and the relatively high internal exposure levels.
高氯酸盐和氯酸盐由于其在水中的高溶解度和抗降解性，被认为是环境中普遍存在的无机污染物。先前的研究已经证实了高氯酸盐和氯酸盐对人体甲状腺功能的潜在不良影响，以及对胎儿生长和发育的影响。胎儿在孕妇的子宫中生长和发育，并从她的身体中吸收营养。然而，关于孕妇产前暴露于高氯酸盐和氯酸盐以及相关健康风险的信息仍然有限，特别是在中国。在这项研究中，分析了来自居住在中国南方的孕妇的 430 份血清样本，以确定高氯酸盐和氯酸盐的水平，并通过线性回归、WQS 和 QGC 探索高氯酸盐和氯酸盐与甲状腺功能之间的关系。测量的血清高氯酸盐和氯酸盐水平相对较高，中位数分别为 0.693μg/L 和 1.36μg/L。19.7%的孕妇的高氯酸盐暴露剂量估计超过了美国环保署的参考剂量，表明存在潜在的健康风险。尽管血清高氯酸盐与甲状腺激素水平之间没有发现显著的关联，但考虑到孕妇在怀孕期间对化学品的敏感性以及相对较高的内部暴露水平，中国南方孕妇暴露于高氯酸盐的情况令人担忧。
