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Unlocking methodological insights on oncology efficacy endpoints: from statistical to clinical and vice versa. Letter to the editor regarding 'Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2- advanced breast cancer: final overall survival results of MONARCH 3' by M. P. Goetz et al.

作者信息

De Sanctis R, Bruzzi P, Zambelli A

机构信息

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan.

Department of Health Sciences, University of Genoa, Genova, Italy.

出版信息

Ann Oncol. 2024 Dec;35(12):1201-1202. doi: 10.1016/j.annonc.2024.08.2345. Epub 2024 Sep 3.

DOI:10.1016/j.annonc.2024.08.2345
PMID:39236982
Abstract
摘要

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To explain the unexplainable in MONARCH 3 overall survival: the restricted mean survival time. Letter to the Editor regarding 'Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2- advanced breast cancer: Final overall survival results of MONARCH 3' by M. P. Goetz et al.
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Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2- advanced breast cancer: final overall survival results of MONARCH 3.阿贝西利联合非甾体芳香化酶抑制剂作为 HR+/HER2-晚期乳腺癌的初始治疗:MONARCH 3 的最终总生存结果。
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Abemaciclib plus non-steroidal aromatase inhibitor or fulvestrant in women with HR+/HER2- advanced breast cancer: Final results of the randomized phase III MONARCH plus trial.阿贝西利联合非甾体芳香化酶抑制剂或氟维司群用于激素受体阳性/人表皮生长因子受体2阴性晚期乳腺癌女性患者:随机III期MONARCH plus试验的最终结果
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Pre-existing and emerging immune-mediated diseases in patients with breast cancer undergoing cyclin-dependent kinases 4/6 inhibitors and endocrine therapy.接受细胞周期蛋白依赖性激酶4/6抑制剂和内分泌治疗的乳腺癌患者中既往存在和新出现的免疫介导疾病。
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