小儿MN1::BEND2融合性脑肿瘤缺乏经典成星形细胞瘤特征。
Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors.
作者信息
Chapman Nicholas, Iqbal Mohammed, Walker Adam D, Hawes Debra, Davidson Tom Belle, Robison Nathan, Tamrazi Benita, Ji Jianling, Krieger Mark D, Cotter Jennifer A
机构信息
Department of Surgery and Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Neurosurgery, University of Texas, Dell Medical School, Austin, Texas, USA.
出版信息
Brain Pathol. 2025 Mar;35(2):e13297. doi: 10.1111/bpa.13297. Epub 2024 Sep 5.
Three distinct MN1::BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.
三名儿科患者中出现的三种不同的MN1::BEND2融合阳性肿瘤。(A) 每位患者的临床病程各不相同，部分原因是初始诊断存在差异。每位患者对全切除反应良好，在最后一次随访时病情稳定。(B) 组织学多样性、缺乏典型的成纤维细胞瘤显著特征以及关键标志物的免疫表达可变，使得显微镜诊断具有挑战性。
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