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Niacin, food intake and cardiovascular effects.

作者信息

Guyton John R, Boden William E

机构信息

Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.

出版信息

Nat Med. 2024 Sep;30(9):2444-2445. doi: 10.1038/s41591-024-03220-2. Epub 2024 Sep 5.

DOI:10.1038/s41591-024-03220-2
PMID:39237629
Abstract
摘要

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Niacin, food intake and cardiovascular effects.烟酸、食物摄入与心血管效应。
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Niacin: another look at an underutilized lipid-lowering medication.烟酸：另一种被低估的降脂药物。
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Role of niacin in current clinical practice.烟酸在当前临床实践中的作用。
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Clinical Inquiries: Does niacin decrease cardiovascular morbidity and mortality in CVD patients?临床研究问题：烟酸是否能降低心血管疾病（CVD）患者的心血管发病率和死亡率？
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Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be decreased with plant-based diets, phosphate binders, niacin, and avoidance of phosphate additives.生物可利用的膳食磷酸盐是心血管疾病的一个介质，采用植物性饮食、使用磷酸盐结合剂、烟酸以及避免使用磷酸盐添加剂可能会降低其含量。
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引用本文的文献

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Association of dietary niacin intake with all-cause and cardiovascular mortality: National Health and Nutrition Examination Survey (NHANES) 2003-2018.膳食烟酸摄入量与全因和心血管死亡率的关联：2003-2018 年国家健康和营养调查（NHANES）。
Sci Rep. 2024 Nov 16;14(1):28313. doi: 10.1038/s41598-024-79986-9.

本文引用的文献

1
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.烟酸的终末代谢产物可促进血管炎症，并导致心血管疾病风险增加。
Nat Med. 2024 Feb;30(2):424-434. doi: 10.1038/s41591-023-02793-8. Epub 2024 Feb 19.
2
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.补充维生素和矿物质预防和治疗心血管疾病：JACC 焦点研讨会。
J Am Coll Cardiol. 2021 Feb 2;77(4):423-436. doi: 10.1016/j.jacc.2020.09.619.
3
Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review.
烟酸：广谱脂质药物。50周年回顾
J Intern Med. 2005 Aug;258(2):94-114. doi: 10.1111/j.1365-2796.2005.01528.x.
4
Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia.缓释烟酸对伴有致动脉粥样硬化血脂异常的代谢综合征中非酯化脂肪酸通量的影响。
Am J Cardiol. 2005 Jun 1;95(11):1309-13. doi: 10.1016/j.amjcard.2005.01.073.
5
Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes.抑制血浆游离脂肪酸可上调人骨骼肌中的过氧化物酶体增殖物激活受体（PPAR）α和δ以及PPAR共激活因子1α，但不会上调脂质调节基因。
J Mol Endocrinol. 2004 Oct;33(2):533-44. doi: 10.1677/jme.1.01499.
6
Sympathetic activity as the cause of the morning increase in cardiac events. A likely culprit, but the evidence remains circumstantial.
Circulation. 1995 May 15;91(10):2508-9. doi: 10.1161/01.cir.91.10.2508.
7
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin.冠心病药物研究项目患者的15年死亡率：烟酸的长期益处
J Am Coll Cardiol. 1986 Dec;8(6):1245-55. doi: 10.1016/s0735-1097(86)80293-5.
8
Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid.
Acta Med Scand. 1988;223(5):405-18. doi: 10.1111/j.0954-6820.1988.tb15891.x.
9
Increased morning incidence of myocardial infarction in the ISAM Study: absence with prior beta-adrenergic blockade. ISAM Study Group.
Circulation. 1989 Oct;80(4):853-8. doi: 10.1161/01.cir.80.4.853.