Cataltepe Esra, Ceker Eda, Fadiloglu Ayse, Gungor Fatih, Karakurt Nermin, Ulger Zekeriya, Varan Hacer Dogan
Department of Geriatric Medicine, Gazi University Faculty of Medicine, 06560, Ankara, Türkiye.
Eur Geriatr Med. 2024 Dec;15(6):1731-1738. doi: 10.1007/s41999-024-01047-1. Epub 2024 Sep 5.
Current measures of frailty often rely on subjective assessments or complex scoring systems. This study aims to investigate the utility of a novel anthropometric measure, the Weight-Adjusted Waist Index (WWI), as a simple and objective predictive marker for frailty in older adults.
This cross-sectional study included 847 patients aged 65 years and older. Comprehensive geriatric assessments and anthropometric measurements were conducted. Frailty was diagnosed using the Clinical Frailty Scale (CFS). The association between WWI and frailty was analyzed using multivariate logistic regression analysis.
The mean age of the participants was 74.9 ± 6 years, with 56.3% (n = 477) being women and 14.8% (n = 125) classified as frail. The frail group had a significantly higher WWI than the non-frail group (p < 0.001). In multivariate logistic regression analysis, WWI remained significantly associated with frailty, even after adjusting for other potential confounding factors (OR = 2.51, 95% CI 1.77-3.57, p < 0.001). The predictive ability of WWI for frailty was measured by the area under the receiver operating characteristic (ROC) curve, which was 0.705 (95% CI 0.67-0.73; p < 0.001). The optimal WWI threshold for predicting frailty was identified as > 12.
The Weight-Adjusted Waist Index shows significant potential as a simple and objective predictive marker for frailty in older adults.
目前对衰弱的评估方法通常依赖主观评估或复杂的评分系统。本研究旨在探讨一种新的人体测量指标——体重调整腰围指数（WWI）作为老年人衰弱的简单客观预测标志物的效用。
这项横断面研究纳入了847名65岁及以上的患者。进行了全面的老年医学评估和人体测量。使用临床衰弱量表（CFS）诊断衰弱。采用多因素逻辑回归分析WWI与衰弱之间的关联。
参与者的平均年龄为74.9±6岁，其中56.3%（n = 477）为女性，14.8%（n = 125）被归类为衰弱。衰弱组的WWI显著高于非衰弱组（p < 0.001）。在多因素逻辑回归分析中，即使在调整了其他潜在混杂因素后，WWI仍与衰弱显著相关（OR = 2.51，95%CI 1.77 - 3.57，p < 0.001）。通过受试者工作特征（ROC）曲线下面积衡量WWI对衰弱的预测能力，其值为0.705（95%CI 0.67 - 0.73；p < 0.001）。预测衰弱的最佳WWI阈值确定为>12。
体重调整腰围指数显示出作为老年人衰弱的简单客观预测标志物的巨大潜力。
