Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul02447, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul02841, Republic of Korea.
Br J Nutr. 2023 Mar 14;129(5):875-887. doi: 10.1017/S0007114522001817. Epub 2022 Jun 17.
Sarcopenic obesity is defined as the presence of high fat mass and low muscle mass combined with low physical function, and it is closely related with the onset of cardiovasular diseases (CVD). The existing anthropometric indices, which are being utilised in clinical practice as predictors of CVD, may also be used to screen sarcopenic obesity, but their feasibility remained unknown. Using cross-sectional data of 2031 participants aged 70-84 years (mean age, 75·9 ± 3·9 years; 49·2 % women) from the Korean Frailty and Aging Cohort Study, we analysed the association of anthropometric indices, including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and weight-adjusted waist index (WWI) with sarcopenic obesity. Body composition was measured using dual-energy X-ray absorptiometry. Higher WWI, WHtR and WC quartiles were associated with higher risk of sarcopenic obesity; the odds ratio (OR) of sarcopenic obesity were highest in the fourth quartile of the WWI (OR: 10·99, 95 % CI: 4·92-24·85, < 0·001). WWI provided the best diagnostic power for sarcopenic obesity in men (area under the receiver operating characteristic curve: 0·781, 95 % CI: 0·751-0·837). No anthropometric indices were significantly associated with sarcopenic obesity in women. WWI was the only index that was negatively correlated with physical function in both men and women. WWI showed the strongest association with sarcopenic obesity, defined by high fat mass and low muscle mass combined with low physical function only in older men. No anthropometric indices were associated with sarcopenic obesity in older women.
肌少症性肥胖定义为体内存在大量脂肪和少量肌肉，同时身体机能下降，与心血管疾病（CVD）的发生密切相关。目前临床上用于预测 CVD 的人体测量学指标也可用于筛查肌少症性肥胖，但这些指标的可行性尚不清楚。本研究利用韩国虚弱和老龄化队列研究中 2031 名 70-84 岁（平均年龄 75.9±3.9 岁；49.2%为女性）参与者的横断面数据，分析了人体测量学指标（包括体重指数、腰围、腰高比和体重调整腰围指数）与肌少症性肥胖的相关性。使用双能 X 射线吸收法测量身体成分。较高的 WWI、WHtR 和 WC 四分位数与肌少症性肥胖的风险增加相关；WWI 四分位数最高的患者患肌少症性肥胖的比值比（OR）最高（OR：10.99，95%CI：4.92-24.85，<0.001）。在男性中，WWI 对肌少症性肥胖的诊断效能最佳（ROC 曲线下面积：0.781，95%CI：0.751-0.837）。在女性中，没有人体测量学指标与肌少症性肥胖显著相关。在男性和女性中，只有 WWI 与身体功能呈负相关。在老年男性中，只有 WWI 与仅由低肌肉量和低身体功能引起的高体脂量和肌少症性肥胖的相关性最强。在老年女性中，没有人体测量学指标与肌少症性肥胖相关。
