Department of Mental Health, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
School of Mental Health, Wenzhou Medical University, Wenzhou, China.
BMC Psychiatry. 2024 Sep 5;24(1):598. doi: 10.1186/s12888-024-06023-4.
Major depressive disorder (MDD) is often accompanied by psychotic symptoms. However, few studies have examined the relationship between psychotic symptoms and endocrine factors in adolescent patients with MDD. Therefore, this study aimed to investigate the prevalence and related endocrine clinical factors of psychotic symptoms in Chinese adolescent patients with MDD.
In total, 601 patients (aged 12-18) with MDD were recruited. The Patient Health Questionnaire - 9 items (PHQ - 9) was utilized for assessing depressive symptoms. Psychotic symptoms were assessed through clinical interviews. Prolactin (PRL), thyroid-stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), and free thyroxine (FT4) were also measured.
The incidence of psychotic symptoms in adolescent patients with MDD was 22.6%. The findings demonstrated that age, self-harming behavior, PHQ-9 score, FT4, and normalized PRL were independently associated with psychotic symptoms in patients with MDD (All p < 0.05).
PRL and FT4 levels are more likely to be abnormally elevated in major depressive adolescents with psychotic symptoms. Prolactin and thyroid hormones in patients with MDD should be paid more attention.
重度抑郁症（MDD）常伴有精神病症状。然而，很少有研究探讨精神病症状与青少年 MDD 患者内分泌因素之间的关系。因此，本研究旨在调查中国青少年 MDD 患者精神病症状的患病率及其相关内分泌临床因素。
共纳入 601 例（年龄 12-18 岁）MDD 患者。采用患者健康问卷-9 项（PHQ-9）评估抑郁症状。通过临床访谈评估精神病症状。还测量了催乳素（PRL）、促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、游离三碘甲状腺原氨酸（FT3）、甲状腺素（T4）和游离甲状腺素（FT4）。
MDD 青少年患者精神病症状的发生率为 22.6%。研究结果表明，年龄、自残行为、PHQ-9 评分、FT4 和校正后 PRL 与 MDD 患者的精神病症状独立相关（均 p<0.05）。
有精神病症状的 MDD 青少年中，PRL 和 FT4 水平更有可能异常升高。应更加关注 MDD 患者的催乳素和甲状腺激素。
