Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Front Immunol. 2024 Aug 22;15:1423784. doi: 10.3389/fimmu.2024.1423784. eCollection 2024.
Diabetic nephropathy, a common and severe complication of diabetes, is the leading cause of end-stage renal disease, ultimately leading to renal failure and significantly affecting the prognosis and lives of diabetics worldwide. However, the complexity of its developmental mechanisms makes treating diabetic nephropathy a challenging task, necessitating the search for improved therapeutic targets. Intercellular communication underlies the direct and indirect influence and interaction among various cells within a tissue. Recently, studies have shown that beyond traditional communication methods, tunnel nanotubes, exosomes, filopodial tip vesicles, and the fibrogenic niche can influence pathophysiological changes in diabetic nephropathy by disrupting intercellular communication. Therefore, this paper aims to review the varied roles of intercellular communication in diabetic nephropathy, focusing on recent advances in this area.
糖尿病肾病是糖尿病常见且严重的并发症之一，是终末期肾病的主要病因，最终导致肾衰竭，并严重影响全球糖尿病患者的预后和生活。然而，其发病机制的复杂性使得治疗糖尿病肾病成为一项具有挑战性的任务，需要寻找更好的治疗靶点。细胞间通讯是组织内各种细胞之间直接和间接影响和相互作用的基础。最近的研究表明，除了传统的通讯方式外，隧道纳米管、外泌体、丝状伪足尖端囊泡和纤维化龛还可以通过破坏细胞间通讯来影响糖尿病肾病的病理生理变化。因此，本文旨在综述细胞间通讯在糖尿病肾病中的多种作用，重点介绍该领域的最新进展。
