Lodha Shweta, Loriaux Daniel, Faulkner Amanda L, Pearson Kathyrn, Shah Shreyansh
Department of Internal Medicine, Duke University School of Medicine, Durham, USA.
Department of Internal Medicine, Duke University Medical Center, Durham, USA.
Cureus. 2024 Aug 6;16(8):e66308. doi: 10.7759/cureus.66308. eCollection 2024 Aug.
Calcium channel blockers (CCBs) are commonly used in the management of multiple diseases, including hypertension, arrhythmia, and vasospastic disorder. Nimodipine, a dihydropyridine CCB, has demonstrated utility in preserving hearing following vestibular schwannoma resection surgery. Due to its widespread use, CCB overdose is common. This case report presents a unique case of CCB toxicity in a 56-year-old female with end-stage liver dysfunction. The patient developed vasodilatory shock after receiving a single dose of prophylactic nimodipine following vestibular schwannoma surgery. The primary objective of this report is to highlight the unique risk for CCB toxicity that exists for patients with advanced liver disease who receive nimodipine in the perioperative setting.
钙通道阻滞剂（CCB）常用于多种疾病的治疗，包括高血压、心律失常和血管痉挛性疾病。尼莫地平是一种二氢吡啶类CCB，已证明在听神经瘤切除术后保护听力方面具有效用。由于其广泛使用，CCB过量很常见。本病例报告介绍了一名56岁终末期肝功能不全女性发生CCB中毒的独特病例。该患者在听神经瘤手术后接受单剂量预防性尼莫地平治疗后发生血管舒张性休克。本报告的主要目的是强调围手术期接受尼莫地平治疗的晚期肝病患者存在CCB中毒的独特风险。
