Muenchrath Mark M, Gilani S Omar, Christiansen Sandy, Landreth Scott P, Ricelli L P
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA.
Department of Radiology, Oregon Health and Science University, Portland, OR, USA.
Interv Pain Med. 2022 Feb 17;1(1):100070. doi: 10.1016/j.inpm.2022.100070. eCollection 2022 Mar.
Chronic neuropathic pain has a prevalence between 7 and 11% of the population. Management typically involves pharmacologic agents, however, a high number needed to treat (NNT) and undesirable side effects limit their utility. Neuromodulation techniques, such as peripheral nerve (PNS) and spinal cord stimulators (SCS), have been utilized successfully in the treatment of chronic neuropathic pain syndromes. To date, there is limited evidence supporting use of PNS for cancer-related neuropathic pain.
An 83 year old male presented to the outpatient pain clinic after experiencing worsening pain related to brachial plexus invasion from a left anterior chest wall metastatic lesion from a primary lung cancer. His treatment had included a left upper lobectomy followed by radiation and an initial round of chemotherapy. The chest wall metastatic lesion was unable to be resected. After subsequent tumor progression, the mass caused a worsening dull, achy pain in his left shoulder radiating down his left arm. A PNS system was implanted targeting the inferior trunk of the brachial plexus. The patient's pain score decreased after activation of the device and he was able to rely solely on the stimulator for pain management until his eventual death.
This patient experienced a substantial reduction in pain and improvement in his quality of life through his eventual death suggesting PNS as a viable palliative pain option for neuropathic pain due to tumor invasion.
慢性神经性疼痛在人群中的患病率为7%至11%。治疗通常涉及药物治疗,然而,高治疗所需人数(NNT)和不良副作用限制了它们的效用。神经调节技术,如周围神经(PNS)和脊髓刺激器(SCS),已成功用于治疗慢性神经性疼痛综合征。迄今为止,支持使用PNS治疗癌症相关神经性疼痛的证据有限。
一名83岁男性因原发性肺癌左前胸壁转移瘤侵犯臂丛神经导致疼痛加重,前来门诊疼痛诊所就诊。他的治疗包括左上肺叶切除术,随后进行放疗和第一轮化疗。胸壁转移瘤无法切除。在随后的肿瘤进展后,肿块导致他左肩出现越来越严重的钝痛,并向下放射至左臂。植入了一个针对臂丛神经下干的PNS系统。设备激活后,患者的疼痛评分降低,并且在最终死亡前,他能够仅依靠刺激器进行疼痛管理。
该患者的疼痛显著减轻,生活质量得到改善,直至最终死亡,这表明PNS作为肿瘤侵犯所致神经性疼痛的一种可行的姑息性疼痛治疗选择。