Asemi Reza, Ahmadi Asouri Sahar, Aghadavod Esmat, Jamilian Mehri
Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Department of Biochemistry, Kashan University of Medical Sciences, Kashan.
Ann Med Surg (Lond). 2024 Jul 5;86(9):5218-5223. doi: 10.1097/MS9.0000000000002349. eCollection 2024 Sep.
Oxidative stress and inflammation play a vital function in the pathophysiology of polycystic ovary syndrome (PCOS) and infertility. The aim of this work was to control the impacts of vitamin D intake on metabolic profiles in infertile subjects with PCOS.
This randomized, double-blinded, placebo-controlled clinical trial was carried out among 40 infertile women with PCOS. Subjects were randomly divided into two intervention groups to take either 50 000 IU vitamin D (=20) or placebo (=20) weekly for 8 weeks. Metabolic profiles and few inflammatory cytokines expression evaluated on peripheral blood mononuclear cells (PBMCs) of participants, using real-time polymerase chain reaction (RT-PCR) method.
Vitamin D intake decreased high-sensitivity C-reactive protein (hs-CRP) (-0.9±1.1 vs. 0.3±0.9 mg/l, =0.002) and elevated total antioxidant capacity (TAC) levels (49.2±60.2 vs. -50.6±161.8 mmol/l, =0.02) compared with placebo; but no significant effects on other metabolic parameters were observed. Moreover, a significant downregulation of tumor necrosis factor alpha (TNF-α) expression (=0.03) was observed after taking vitamin D compared with the placebo.
Overall, vitamin D intake for eight weeks had beneficial impacts on hs-CRP, TAC, and TNF-α among infertile women with PCOS.
氧化应激和炎症在多囊卵巢综合征（PCOS）及不孕症的病理生理学中起着至关重要的作用。本研究旨在控制维生素D摄入对PCOS不孕患者代谢谱的影响。
本随机、双盲、安慰剂对照临床试验在40例PCOS不孕女性中进行。受试者被随机分为两个干预组，分别每周服用50000 IU维生素D（=20例）或安慰剂（=20例），共8周。采用实时聚合酶链反应（RT-PCR）方法评估参与者外周血单个核细胞（PBMC）的代谢谱及几种炎性细胞因子的表达。
与安慰剂相比，维生素D摄入可降低高敏C反应蛋白（hs-CRP）水平（-0.9±1.1 vs. 0.3±0.9 mg/l，P=0.002），并提高总抗氧化能力（TAC）水平（49.2±60.2 vs. -50.6±161.8 mmol/l，P=0.02）；但对其他代谢参数未观察到显著影响。此外，与安慰剂相比，服用维生素D后肿瘤坏死因子α（TNF-α）表达显著下调（P=0.03）。
总体而言，为期8周的维生素D摄入对PCOS不孕女性的hs-CRP、TAC和TNF-α具有有益影响。
