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Breaking the silence: gene therapy offers hope for OTOF-mediated hearing loss, editorial.

作者信息

Hussain Syed Ahmed Shahzaeem, Ali Mohammad Haris, Imtiaz Muhammad Hassan, Al Hasibuzzaman Md

机构信息

Department of ENT, Shaikh Zayed Hospital, Shaikh Zayed Medical Complex.

Shaikh Khalifa Bin Zayed Al-Nahyan Medical and Dental College, Lahore, Pakistan.

出版信息

Ann Med Surg (Lond). 2024 Jul 8;86(9):4950-4951. doi: 10.1097/MS9.0000000000002360. eCollection 2024 Sep.

Abstract
摘要

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Breaking the silence: gene therapy offers hope for OTOF-mediated hearing loss, editorial.
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本文引用的文献

1
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial.
Lancet. 2024 May 25;403(10441):2317-2325. doi: 10.1016/S0140-6736(23)02874-X. Epub 2024 Jan 24.
2
Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin.
Hum Genet. 2023 Feb;142(2):289-304. doi: 10.1007/s00439-022-02504-2. Epub 2022 Nov 16.
3
Cochlear Implantation Outcomes in Patients With Mutations.
Front Neurosci. 2020 May 21;14:447. doi: 10.3389/fnins.2020.00447. eCollection 2020.
4
Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model.
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4496-4501. doi: 10.1073/pnas.1817537116. Epub 2019 Feb 19.
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The Epidemiology of Deafness.
Cold Spring Harb Perspect Med. 2019 Sep 3;9(9):a033258. doi: 10.1101/cshperspect.a033258.
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Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss.
Hum Genet. 2016 Apr;135(4):441-450. doi: 10.1007/s00439-016-1648-8. Epub 2016 Mar 11.
9
New treatment options for hearing loss.
Nat Rev Drug Discov. 2015 May;14(5):346-65. doi: 10.1038/nrd4533. Epub 2015 Mar 20.

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