Eslami Hosein, Katebi Katayoun, Ghaffaripour Saleh Sevil, Mirizadeh Lalehsan, Hashemi Mohsen
Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Private Practice, Tabriz, Iran.
J Res Med Sci. 2024 Jul 12;29:33. doi: 10.4103/jrms.jrms_660_23. eCollection 2024.
Oxidative stress has a role in many pathologic conditions, including oral diseases and temporomandibular joint disorders (TMDs) pathophysiology. This study compared the selected oxidative biomarkers' levels in TMD patients and healthy controls in a systematic review and meta-analysis.
Medline/PubMed, Scopus, Web of Science, Google Scholar, and Embase were systematically searched for English articles up to October 2022 using MeSH and free keywords. Joanna Briggs Institute checklist was used to assess the risk of bias. Differences between biomarker levels in TMD patients were compared to the control group.
Ten case-control studies were included based on inclusion and exclusion criteria with a total of 659 patients: 314 with TMD and 345 healthy controls. The studies investigated 15 markers, including total oxidant status (TOS), total antioxidant status, and malondialdehyde (MDA). There was a significant difference in the salivary MDA of patients with TMD in comparison with healthy people; standard mean difference = 3.22 (95% confidence interval [CI]: 0.28-6.16); = 96.0%). The Antioxidant status in serum was significantly lower in patients with TMD in comparison with healthy people; weighted mean difference = -0.52 (95% CI: -0.90 to -0.14; = 97.0%). The result of TOS was inconclusive.
Salivary MDA and serum total antioxidative status measurements may be used as a biomarker for diagnosing TMD. Due to the lack of sufficient evidence, it is not possible to express a definite relation between the amount and type of marker and TMD diagnosis, which suggests that more case-control studies with larger sample sizes are required.
氧化应激在许多病理状况中起作用，包括口腔疾病和颞下颌关节紊乱病（TMDs）的病理生理学。本系统评价和荟萃分析比较了TMD患者和健康对照者中选定的氧化生物标志物水平。
使用医学主题词表（MeSH）和自由关键词，对Medline/PubMed、Scopus、科学网、谷歌学术和Embase进行系统检索，以查找截至2022年10月的英文文章。使用乔安娜·布里格斯研究所检查表评估偏倚风险。将TMD患者生物标志物水平与对照组进行比较。
根据纳入和排除标准纳入了10项病例对照研究，共659例患者：314例TMD患者和345例健康对照者。这些研究调查了15种标志物，包括总氧化剂状态（TOS）、总抗氧化剂状态和丙二醛（MDA）。与健康人相比，TMD患者唾液中的MDA有显著差异；标准平均差=3.22（95%置信区间[CI]：0.28 - 6.16）；P = 96.0%）。与健康人相比，TMD患者血清中的抗氧化剂状态显著较低；加权平均差=-0.52（95%CI：-0.90至-0.14；P = 97.0%）。TOS的结果尚无定论。
唾液MDA和血清总抗氧化状态测量可作为诊断TMD的生物标志物。由于缺乏足够的证据，无法明确标志物的数量和类型与TMD诊断之间的关系，这表明需要更多样本量更大的病例对照研究。
