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本文引用的文献

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Intraoperative Management of the Recurrent Laryngeal Nerve Transected or Invaded by Thyroid Cancer.甲状腺癌累及或切断喉返神经的术中处理。
Front Endocrinol (Lausanne). 2022 Jun 9;13:884866. doi: 10.3389/fendo.2022.884866. eCollection 2022.
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Immediate Intraoperative Repair of the Recurrent Laryngeal Nerve in Thyroid Surgery.甲状腺手术中即时修复喉返神经。
Laryngoscope. 2021 Jun;131(6):1429-1435. doi: 10.1002/lary.29204. Epub 2020 Oct 29.
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A method to repair the recurrent laryngeal nerve during thyroidectomy.一种在甲状腺切除术中修复喉返神经的方法。
Can J Surg. 2018 Aug;61(4):278-282. doi: 10.1503/cjs.010317.
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Impact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model.喉返神经损伤对仔猪模型口咽肌肉活动和感觉运动整合的影响。
J Appl Physiol (1985). 2018 Jul 1;125(1):159-166. doi: 10.1152/japplphysiol.00963.2017. Epub 2018 Apr 12.
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Longitudinal voice outcomes following laryngeal reinnervation via vagus-to-recurrent laryngeal nerve anastomosis after vagal nerve sacrifice: a case series.迷走神经切断后经迷走神经至喉返神经吻合术行喉再支配后的纵向嗓音结果:病例系列
Ann Otol Rhinol Laryngol. 2015 Feb;124(2):153-7. doi: 10.1177/0003489414546397. Epub 2014 Aug 13.
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Outcome with immediate direct anastomosis of recurrent laryngeal nerves injured during thyroidectomy.甲状腺切除术中喉返神经损伤后即刻直接吻合的结果。
Laryngoscope. 2014 Jun;124(6):1402-8. doi: 10.1002/lary.24450. Epub 2013 Nov 13.
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Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: international standards guideline statement.甲状腺和甲状旁腺手术中的电生理喉返神经监测:国际标准指南声明。
Laryngoscope. 2011 Jan;121 Suppl 1:S1-16. doi: 10.1002/lary.21119.
8
Diagnosis of recurrent laryngeal nerve palsy after thyroidectomy: a systematic review.甲状腺切除术后喉返神经麻痹复发的诊断:一项系统评价
Int J Clin Pract. 2009 Apr;63(4):624-9. doi: 10.1111/j.1742-1241.2008.01875.x.
9
ELECTROMYOGRAPHY OF EXTRINSIC LARYNGEAL MUSCLES DURING PHONATION OF DIFFERENT VOWELS.
Ann Otol Rhinol Laryngol. 1964 Mar;73:248-54. doi: 10.1177/000348946407300127.
10
Neurorrhaphy of the recurrent laryngeal nerve.喉返神经神经缝合术
J Am Coll Surg. 2003 Jul;197(1):52-7. doi: 10.1016/S1072-7515(03)00235-7.

肿瘤学背景下喉返神经修复/重建的长期结果

Long-Term Outcomes of Recurrent Laryngeal Nerve Repair/Reconstruction in Oncological Settings.

作者信息

Mandavgane Mayank, Kumar Vineet, Mokhale Kunal, Bindu Ameya, Mantri Mayur, Mathews Saumya, Jaiswal Dushyant, Shankhdhar Vinay Kant

机构信息

Department of Plastic and Reconstructive Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.

出版信息

Indian J Surg Oncol. 2024 Sep;15(3):469-473. doi: 10.1007/s13193-024-01932-y. Epub 2024 Mar 25.

DOI:10.1007/s13193-024-01932-y
PMID:39239433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11371961/
Abstract

Vocal cord paralysis results from involvement of the recurrent laryngeal nerve (RLN), either before the surgery or following excision. Coaptation of the resected edges utilising microsurgical techniques is the most promising therapeutic strategy available for RLN excision. The RLN can be repaired by direct epineural coaptation or using nerve grafts adhering to recommended microsurgical techniques. This article aims to convey our experience with RLN resections/injuries and their subsequent effects. We assessed the RLN repairs that our institute had completed from April 2018 to September 2023(5 years and 5 months) including follow-up of minimum 1 year. The Functional Oral Intake Scale (FOSI) was applied to assess dysphagia, aspiration risk, and glottic gap by laryngoscopy, and GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) comprised the basis for the assessment of voice quality by speech specialists. Surgical technique included using 9-0 Ethilon either for primary repair or for repair with a nerve graft. Ten patients were included in the study; six (60%) of them were male with the median age of 32 years. At 12-month follow-up, only 10% ( = 1) was found to have dysphagia. Only 10% ( = 1) had a mild harsh voice. This same patient was the only patient to show a minimal remnant glottic gap. Ten percent ( = 1) patient showed B/l cord mobility at 12 months, while 30% ( = 3) showed flickering movements of the affected vocal cord. In all the patients, the opposite vocal cord was found to be compensating. Thus, immediate repair of RLN is helpful along with the general physiological adaptation of vocal cords to improve phonation and reduce aspiration and dysphagia risks, thus helping to improve the quality of life. The right procedure should choose from the armoury after careful intraoperative assessment.

摘要

声带麻痹是由手术前或切除术后喉返神经(RLN)受累引起的。利用显微外科技术对切除边缘进行对合是目前可用于RLN切除的最有前景的治疗策略。可以通过直接神经外膜对合或使用符合推荐显微外科技术的神经移植物来修复RLN。本文旨在分享我们在RLN切除/损伤及其后续影响方面的经验。我们评估了我院在2018年4月至2023年9月(5年零5个月)期间完成的RLN修复情况,包括至少1年的随访。应用功能性口服摄入量表(FOSI)通过喉镜检查评估吞咽困难、误吸风险和声门间隙,言语专家则以GRBAS(分级、粗糙、呼吸音、无力、紧张)为基础评估嗓音质量。手术技术包括使用9-0 Ethilon缝线进行一期修复或神经移植修复。本研究纳入了10例患者;其中6例(60%)为男性,中位年龄为32岁。在12个月的随访中,仅10%(=1)的患者存在吞咽困难。仅有10%(=1)的患者嗓音轻度粗糙。同一患者是唯一显示声门间隙极小残留的患者。10%(=1)的患者在12个月时双侧声带活动正常,而30%(=3)的患者患侧声带出现颤动。在所有患者中,均发现对侧声带存在代偿。因此,RLN的即刻修复以及声带的一般生理适应性有助于改善发声并降低误吸和吞咽困难风险,从而有助于提高生活质量。应在术中仔细评估后从可用方法中选择正确的术式。