Baldetti Luca, Busnardo Elena, Pazzanese Vittorio, Ricchetti Gianluca, Barone Giuseppe, Sacchi Stefania, Calvo Francesco, Gramegna Mario, Pieri Marina, Ingallina Giacomo, Camici Paolo Guido, Ajello Silvia, Scandroglio Anna Mara
Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Nuclear Imaging Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
ESC Heart Fail. 2025 Feb;12(1):683-687. doi: 10.1002/ehf2.15053. Epub 2024 Sep 6.
Formal assessment of myocardial viability (MV) is challenging in acute myocardial infarction-related cardiogenic shock (AMI-CS) patients receiving Impella mechanical circulatory support, as the cardiac magnetic resonance gold standard technique is not feasible due to the metallic components of the device. 18-fluorodesoxyglucose metabolic myocardial positron emission tomography (FDG-PET) may represent a valid and feasible alternative to obtain semi-quantitative and objective evidence of MV during Impella support. We hereby report the first series of sequential AMI-CS patients who received FDG-PET scanning to assess MV during Impella support to demonstrate the safety and feasibility of this approach. In this cohort no adverse events occurred during FDG-PET scans, and all images were of excellent quality. This study provides a pragmatic guidance on how to perform this imaging modality during Impella support and finally confirms the safety and feasibility of this advanced imaging method also in this vulnerable cohort of patients.
对于接受Impella机械循环支持的急性心肌梗死相关心源性休克（AMI-CS）患者，心肌活力（MV）的正式评估具有挑战性，因为由于该设备的金属部件，心脏磁共振金标准技术不可行。18-氟脱氧葡萄糖代谢心肌正电子发射断层扫描（FDG-PET）可能是在Impella支持期间获得MV的半定量和客观证据的有效且可行的替代方法。我们在此报告了首批接受FDG-PET扫描以评估Impella支持期间MV的连续性AMI-CS患者系列，以证明该方法的安全性和可行性。在该队列中，FDG-PET扫描期间未发生不良事件，并且所有图像质量都非常好。本研究为如何在Impella支持期间进行这种成像方式提供了实用指导，并最终证实了这种先进成像方法在这一脆弱患者群体中的安全性和可行性。
