[Metabolic effects of ring-substituted arylalkylguanidines on insulin-sensitive systems. I. Amino-substituted benzylguanidines].

The synthesis of benzylguanidines carrying amino groups and their influence on insulin-sensitive metabolic systems are described. All substances show hypoglycemic activity in mice with intact metabolism. (3-Acetamido-benzyl)guanidine is most effective; the blood glucose concentration is lowered by 55%, accompanied by only a weak increase in serum lactate concentration; the glucose oxidation of epididymal fat cells of the rat remains unaffected.