Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Parkinsonism Relat Disord. 2024 Nov;128:107125. doi: 10.1016/j.parkreldis.2024.107125. Epub 2024 Sep 2.
Neurodegenerative diseases (NDDs) result from a complex interplay of genetic, environmental and aging factors. A balanced diet and adequate physical activity (PA) are recognized as pivotal components among modifiable environmental factors. The independent impact on NDD incidence has been previously debated. This investigation seeks to delineate the association between PA and NDDs across various levels of adherence to a plant-based diet.
In this study, a cohort of 368,934 participants from the UK Biobank was analyzed. Total physical activity (TPA) levels and healthful plant-based diet index (hPDI) were calculated and categorized. A multiple adjusted Cox model was utilized to evaluate the influence of TPA and hPDI on common NDDs, respectively.
Finally, 4602 identified cases diagnosed as Alzheimer's disease (AD), Parkinson's disease (PD) or amyotrophic lateral sclerosis (ALS). We found that higher TPA was significantly associated with a reduced risk of developing AD (Q3: HR 0.87; Q4: HR 0.78) and PD (Q3: HR 0.86; Q4: HR 0.81). The protective effect was further accentuated with adherence to a plant-based diet. However, these connections were not observed in the analysis of ALS regardless of dietary patterns.
Our findings underscore a significant association between higher TPA and reduced risks of AD and PD, with an enhanced effect observed in conjunction with a plant-based diet. This study contributes to addressing the knowledge gap regarding the combined impact of TPA and a plant-based diet on NDDs occurrence, providing insights into potential underlying mechanisms.
神经退行性疾病（NDDs）是由遗传、环境和衰老因素的复杂相互作用引起的。均衡的饮食和充足的身体活动（PA）被认为是可改变的环境因素中的关键组成部分。PA 对 NDD 发病率的独立影响此前曾有争议。本研究旨在探讨不同植物性饮食依从程度下 PA 与 NDDs 之间的关联。
本研究分析了来自英国生物库的 368934 名参与者。计算并分类了总身体活动（TPA）水平和健康植物性饮食指数（hPDI）。使用多因素调整 Cox 模型分别评估 TPA 和 hPDI 对常见 NDDs 的影响。
最终，确定了 4602 例阿尔茨海默病（AD）、帕金森病（PD）或肌萎缩侧索硬化症（ALS）的病例。我们发现，较高的 TPA 与 AD（Q3：HR 0.87；Q4：HR 0.78）和 PD（Q3：HR 0.86；Q4：HR 0.81）发病风险降低显著相关。遵循植物性饮食时，保护作用进一步增强。然而，无论饮食模式如何，在 ALS 分析中均未观察到这些关联。
我们的研究结果强调了较高 TPA 与 AD 和 PD 发病风险降低之间的显著关联，同时观察到与植物性饮食结合时具有增强的效果。本研究有助于解决 TPA 和植物性饮食对 NDDs 发生的综合影响方面的知识空白，为潜在的机制提供了新的见解。
