焦炉工人血浆 CC16 水平与肺功能变化的关系：2014 年至 2023 年的队列研究。
Association between plasma CC16 levels and lung function changes in coke oven workers: A cohort study from 2014 to 2023.
机构信息
MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, NHC Key Laboratory of Pneumoconiosis, Department of Occupational Health, School of Public Health, Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, Xinjiannan Road 56, Taiyuan City, Shanxi Province 030001, China.
Xishan Coal Electricity Corporation Occupational Disease Prevention and Control Institute, Taiyuan City, Shanxi Province 030053, China.
出版信息
Ecotoxicol Environ Saf. 2024 Oct 1;284:117002. doi: 10.1016/j.ecoenv.2024.117002. Epub 2024 Sep 5.
Club cell secretory protein (CC16) is considered a biological marker indicating lung epithelial and lung permeability. The joint effect of polycyclic aromatic hydrocarbons (PAHs) exposure on CC16 levels and the association between CC16 levels and long-term lung function changes lacks epidemiological evidence. To investigate the effect of PAHs exposure on plasma CC16 levels and the association between CC16 levels and long-term lung function changes, this study enrolled 307 coke oven workers in 2014, measured their baseline concentrations of urinary PAHs metabolites and plasma CC16, with follow-up after nine years. Bayesian kernel machine regression (BKMR) was employed to analyze the effect of mixed PAHs metabolites. The dose-effect association between baseline CC16 levels and lung function during 2014-2023 was explored using restricted cubic spline (RCS) models, and stratified analysis investigated the effect modification of PAHs exposure and smoking status on this association. The median age of the participants was 40 years, with 93.81 % male. The results showed that plasma CC16 levels decreased by 2.02 ng/mL (95 % CI: -3.77, -0.27) among all participants and FVC (% predicted) decreased by 2.87 % (95 % CI: -5.59, -0.14) in the low CC16 group with each unit increase in log-transformed 2-OHNAP. The BKMR model revealed a negative association between PAHs metabolites and both plasma CC16 levels and FVC (% predicted). Plasma CC16 decreased by 1.05 units when all PAHs metabolites at P compared to those at P. After 9 years of follow-up, baseline CC16 levels were significantly associated with follow-up FVC (% predicted), FEV (% predicted), and small airway dysfunction risk. Furthermore, high PAHs exposure and smoking enhanced the association between CC16 and lung function. In conclusion, PAHs exposure decreases CC16 levels, and coking workers with low baseline CC16 levels may experience more severe future lung function decline.
俱乐部细胞分泌蛋白 (CC16) 被认为是一种生物标志物，可指示肺上皮细胞和肺通透性。多环芳烃 (PAHs) 暴露对 CC16 水平的联合影响以及 CC16 水平与长期肺功能变化之间的关联缺乏流行病学证据。为了研究 PAHs 暴露对血浆 CC16 水平的影响以及 CC16 水平与长期肺功能变化之间的关系，本研究于 2014 年招募了 307 名焦炉工人，测量了他们尿液中多环芳烃代谢物和血浆 CC16 的基线浓度，并在九年后进行了随访。贝叶斯核机器回归 (BKMR) 用于分析混合 PAHs 代谢物的影响。使用限制性立方样条 (RCS) 模型探讨了基线 CC16 水平与 2014-2023 年期间肺功能之间的剂量-效应关联，并进行了分层分析，以探讨 PAHs 暴露和吸烟状况对这种关联的影响修饰作用。参与者的中位年龄为 40 岁，93.81%为男性。结果表明，在所有参与者中，血浆 CC16 水平降低了 2.02ng/mL（95%CI：-3.77，-0.27），低 CC16 组中每单位增加 2-OHNAP 的对数转换，FVC（%预测值）降低了 2.87%（95%CI：-5.59，-0.14）。BKMR 模型显示 PAHs 代谢物与血浆 CC16 水平和 FVC（%预测值）呈负相关。与 P 相比，所有 PAHs 代谢物在 P 时，血浆 CC16 降低了 1.05 个单位。随访 9 年后，基线 CC16 水平与随访 FVC（%预测值）、FEV（%预测值）和小气道功能障碍风险显著相关。此外，高 PAHs 暴露和吸烟增强了 CC16 与肺功能之间的关联。总之，PAHs 暴露降低了 CC16 水平，而基线 CC16 水平较低的焦炉工人可能会经历更严重的未来肺功能下降。
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