Liang Shuang, Wang Jingjing, Zhu Wenzhen, Zhang Li
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114205. doi: 10.1016/j.colsurfb.2024.114205. Epub 2024 Sep 3.
Photothermal therapy (PTT), particularly in the near-infrared-II (NIR-II) range, has attracted widespread attention over the past years. However, the accompanied inflammatory responses can result in undesirable side effects and contribute to treatment ineffectiveness. Herein, we introduced a novel biodegradable nanoplatform (CuS/HMON-PEG) capable of PTT and hydrogen sulfide (HS) generation, aimed at modulating inflammation for improved cancer treatment outcomes. The embedded ultrasmall copper sulphide (CuS) nanodots (1-2 nm) possessed favorable photoacoustic imaging (PAI) and NIR-II photothermal capabilities, rendering CuS/HMON-PEG an ideal phototheranostic agent. Upon internalization by 4T1 cancer cells, the hollow mesoporous organosilica nanoparticle (HMON) component could react with the overproduced glutathione (GSH) to produce HS. In addition to the anticipated photothermal tumor ablation and HS-induced mitochondrial dysfunction, the anti-inflammatory regulation was also been demonstrated by the downregulation of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β). More importantly, the modulation of inflammation also promoted wound healing mediated by PTT. This work not only presents a HS-based nanomodulator to boost NIR-II PTT but also provides insights into the construction of novel organic/inorganic hybrid nanosystems.
光热疗法（PTT），尤其是近红外二区（NIR-II）范围内的光热疗法，在过去几年中引起了广泛关注。然而，伴随的炎症反应会导致不良副作用并导致治疗无效。在此，我们引入了一种新型的可生物降解纳米平台（CuS/HMON-PEG），它能够进行光热疗法并产生硫化氢（HS），旨在调节炎症以改善癌症治疗效果。嵌入的超小硫化铜（CuS）纳米点（1-2纳米）具有良好的光声成像（PAI）和NIR-II光热能力，使CuS/HMON-PEG成为一种理想的光热诊疗剂。4T1癌细胞内化后，中空介孔有机硅纳米颗粒（HMON）成分可与过量产生的谷胱甘肽（GSH）反应生成HS。除了预期的光热肿瘤消融和HS诱导的线粒体功能障碍外，肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-1β（IL-1β）的下调也证明了其抗炎调节作用。更重要的是，炎症的调节还促进了由PTT介导的伤口愈合。这项工作不仅提出了一种基于HS的纳米调节剂来增强NIR-II PTT，还为新型有机/无机杂化纳米系统的构建提供了见解。
