College of Materials Science and Engineering, Nanjing Tech University, 211816, Nanjing, Jiangsu, China; School of Pharmaceutical and Chemical, Taizhou University, 318000, Taizhou, Zhejiang, China.
College of Materials Science and Engineering, Nanjing Tech University, 211816, Nanjing, Jiangsu, China.
Talanta. 2025 Jan 1;281:126800. doi: 10.1016/j.talanta.2024.126800. Epub 2024 Sep 1.
Dopamine (DA) is an important neurotransmitter. Abnormal levels of it in human body can increase the risk of many neurological diseases. Thus, developing a simple, sensitive detection method of DA is crucial. In this paper, we reported a "signal-off" anodic PEC sensor based on fluorine-doped tin oxide (FTO) glass modified ZnInS/TiO heterojunction (ZnInS/TiO/FTO) for DA detection. The experimental results show that the ZnInS/TiO/FTO electrode prepared by two-step hydrothermal method has a good photocurrent response performance under visible light. After incubation with DA, the photocurrent response decreases significantly because DA can rapidly oxidizes to polydopamine (PDA) through the action of superoxide radical (·O) and hydroxyl radical (·OH) intermediate species, which are intermediates produced by the ZnInS/TiO/FTO electrode under visible light irradiation. The constructed PEC sensor has a good linear relationship in the concentration range from 0.5 to 1000.0 μM, and its detection limit is 0.253 μM. In addition, the results of the proposed PEC sensor in real serum samples are satisfactory. The PEC sensor provides a promising platform for DA detection, laying the foundation for future advances in disease diagnosis and prevention.
多巴胺（DA）是一种重要的神经递质。人体内其水平异常会增加许多神经疾病的风险。因此，开发一种简单、灵敏的 DA 检测方法至关重要。本文报道了一种基于掺氟氧化锡（FTO）玻璃修饰的 ZnInS/TiO 异质结（ZnInS/TiO/FTO）的“关断型”阳极 PEC 传感器，用于 DA 的检测。实验结果表明，通过两步水热法制备的 ZnInS/TiO/FTO 电极在可见光下具有良好的光电流响应性能。孵育 DA 后，光电流响应显著降低，因为 DA 通过超氧自由基（·O）和羟基自由基（·OH）中间产物的作用，在 ZnInS/TiO/FTO 电极在可见光照射下迅速氧化为聚多巴胺（PDA）。所构建的 PEC 传感器在 0.5 至 1000.0 μM 的浓度范围内具有良好的线性关系，其检测限为 0.253 μM。此外，该 PEC 传感器在实际血清样本中的结果令人满意。该 PEC 传感器为 DA 检测提供了一个有前途的平台，为未来疾病诊断和预防的进展奠定了基础。
