Division of Transplantation and Cellular Therapies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Division of Transplantation and Cellular Therapies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Cell Stem Cell. 2024 Sep 5;31(9):1239-1240. doi: 10.1016/j.stem.2024.07.005.
CD54 and CD58 are adhesion proteins that mediate efficient immune synapse formation. Hammer et al. now show that the abrogation of these molecules in T and NK cells prevents their immune rejection while maintaining their effector function. These findings should significantly help advance our efforts to generate "off-the-shelf" allogeneic products.
CD54 和 CD58 是黏附蛋白，可介导有效的免疫突触形成。Hammer 等人现在表明，在 T 和 NK 细胞中敲除这些分子可防止其免疫排斥，同时保持其效应功能。这些发现应该会极大地帮助我们推进“现成”同种异体产品的研发。
