Graduate Program in Health Technology, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Nursing Department, Universidade Positivo, Curitiba, Brazil.
Wounds. 2024 Aug;36(8):281-289. doi: 10.25270/wnds/23140.
Diabetic foot ulcers (DFUs) present devastating complications. Management of these wounds includes applying a vacuum device composed of a fenestrated tube embedded in a foam dressing and connected to a vacuum pump to collect the fluid in a vessel.
To review the effectiveness of negative pressure wound therapy (NPWT) in treating DFUs and evaluate the clinical outcomes of full and partial wound healing.
A systematic review and meta-analysis of randomized controlled trials was conducted after searching the PubMed, Web of Science, and Cochrane Library databases. Studies that described the use of NPWT in the management of DFUs were included and compared with different interventions for the proposed outcomes.
A total of 14 studies were included, 1 of which was later excluded during internal validation. Wound healing outcomes were analyzed in 2 studies, showing the superiority of total wound healing in the NPWT group. Ten studies compared the effect of different interventions on wound area reduction and 8 of these results were best with NPWT. Three studies showed clinical and statistical homogeneity (I² = 100%), making it possible to conduct a meta-analysis.
Although the articles included in this systematic review have limitations regarding methodological quality and clinical heterogeneity, the results showed the potential benefit of NPWT in healing and wound area reduction. These outcomes are essential in the prevention of amputation in patients with DFU.
糖尿病足溃疡（DFU）会带来严重的并发症。这些伤口的治疗包括应用一种由嵌入泡沫敷料中的多孔管和连接到真空泵的装置，以将容器中的液体收集起来。
综述负压伤口治疗（NPWT）治疗 DFU 的效果，并评估完全和部分伤口愈合的临床结果。
在检索 PubMed、Web of Science 和 Cochrane Library 数据库后，进行了一项随机对照试验的系统评价和荟萃分析。纳入了描述 NPWT 用于 DFU 管理的研究，并与不同干预措施进行了比较，以评估提出的结果。
共纳入 14 项研究，其中 1 项在内部验证时被排除。有 2 项研究分析了伤口愈合结果，显示 NPWT 组的总伤口愈合具有优越性。有 10 项研究比较了不同干预措施对创面面积减少的影响，其中 8 项结果最好的是 NPWT。有 3 项研究显示出临床和统计学同质性（I²=100%），因此可以进行荟萃分析。
尽管本系统评价纳入的文章在方法学质量和临床异质性方面存在局限性，但结果表明 NPWT 在愈合和创面面积减少方面具有潜在的益处。这些结果对于预防 DFU 患者截肢至关重要。
