Widigdo Dwi Ari Murti, Sofro Zaenal Muttaqien, Pangastuti Heny Suseani, Dachlan Ishandono
Department of Nursing, Poltekkes Kemenkes Semarang, Magelang, Yogyakarta, Indonesia.
Department of Physiology, The Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Curr Diabetes Rev. 2024;20(8):1-11. doi: 10.2174/0115733998229877230926073555.
Diabetes mellitus is a complex disorder that requires continuous management to control blood sugar levels and prevent complications. Diabetic foot ulcers (DFU) are the most common complication in diabetic patients. A popular therapy modality with considerable advantages in the management of diabetic foot ulcers today is negative pressure wound therapy (NPWT).
This study aimed to review related articles about the efficacy as well as the complications or adverse effects of using NPWT on the healing of DFUs.
Searching English databases from PubMed, Ebscohost, Proquest and Science Direct was done to identify relevant citations published between January 2017 and January 2022. A combination of terms was used with the boolean formulation of "negative pressure wound therapy OR NPWT" OR "vacuum-assisted closure or VAC" AND "diabetic foot ulcers OR diabetic foot wound" AND "wound healing" AND "Conventional dressings" and map terms were also used for the subject heading. Some potentially relevant citations of articles from the bibliographies are also reviewed.
This study included 8 related articles consisting of 6 RCTs, 1 cohort study and 1 Quasy experimental study. There were various methodological techniques for using NPWT and outcome measures among studies. The results of this literature review showed that NPWT was more efficacious than the other conventional or advanced moist dressings. This therapy revealed a faster healing time with complete wound healing and formation of granulation tissue and reduction in wound size. The complications or adverse effects of NPWT, such as amputation rate, bleeding and pain, were not different from conventional or advanced moist dressings, though.
NPWT was more efficacious than other conventional or advanced moist dressings for the healing of DFUs. However, complications or adverse effects of using this therapy showed no significant difference with other conventional or advanced moist dressings.
糖尿病是一种复杂的疾病，需要持续管理以控制血糖水平并预防并发症。糖尿病足溃疡（DFU）是糖尿病患者最常见的并发症。负压伤口治疗（NPWT）是目前治疗糖尿病足溃疡具有相当优势的一种常用治疗方式。
本研究旨在综述关于使用NPWT治疗DFU愈合的疗效以及并发症或不良反应的相关文章。
检索了PubMed、Ebscohost、Proquest和Science Direct等英文数据库，以识别2017年1月至2022年1月期间发表的相关文献。使用了“负压伤口治疗或NPWT”或“真空辅助闭合或VAC”与“糖尿病足溃疡或糖尿病足伤口”以及“伤口愈合”和“传统敷料”的布尔公式组合术语，并使用主题词映射术语。还对参考文献中一些可能相关的文章引用进行了综述。
本研究纳入了8篇相关文章，包括6项随机对照试验、1项队列研究和1项半实验研究。各研究中使用NPWT的方法技术和结局指标各不相同。该文献综述结果表明，NPWT比其他传统或先进的湿性敷料更有效。这种治疗显示出愈合时间更快，伤口完全愈合，肉芽组织形成，伤口大小减小。不过，NPWT的并发症或不良反应，如截肢率、出血和疼痛，与传统或先进的湿性敷料并无差异。
NPWT在DFU愈合方面比其他传统或先进的湿性敷料更有效。然而，使用这种疗法的并发症或不良反应与其他传统或先进的湿性敷料相比无显著差异。
