Student Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Medical School, University of Pécs, Pécs, Hungary.
Pharmacol Res. 2024 Oct;208:107398. doi: 10.1016/j.phrs.2024.107398. Epub 2024 Sep 4.
Patients with non-alcoholic fatty liver disease (NAFLD) benefit from using synbiotics. However, findings from existing trials remain contentious. Therefore, this meta-analysis evaluated the effects of synbiotics on liver enzymes, blood pressure, inflammation, and lipid profiles in patients with NAFLD.
We searched PubMed, Embase, Cochrane, Scopus, and Web of Science for randomized controlled trials (RCTs) regarding synbiotics supplementation in patients with NAFLD.
The meta-analysis revealed that synbiotics supplementation significantly improved liver enzymes (AST, WMD: -9.12 IU/L; 95 % CI: -13.19 to -5.05; ALT, WMD: -8.53 IU/L; 95 % CI: -15.07 to -1.99; GGT, WMD: -10.42 IU/L; 95 % CI: -15.19 to -5.65), lipid profile (TC, WMD: -7.74 mg/dL; 95 % CI: -12.56 to -2.92), obesity indices (body weight, WMD: -1.95 kg; 95 % CI: -3.69 to -0.22; WC, WMD: -1.40 cm; 95 % CI: -2.71 to -0.10), systolic blood pressure (SBP, WMD: -6.00 mmHg; 95 % CI: -11.52 to -0.49), and inflammatory markers (CRP, WMD: -0.69 mg/L; 95 % CI: -1.17 to -0.21; TNF-α, WMD: -14.01 pg/mL; 95 % CI: -21.81 to -6.20).
Overall, supplementation with synbiotics positively improved liver enzymes, obesity indices, and inflammatory cytokines in patients with NAFLD.
非酒精性脂肪性肝病 (NAFLD) 患者受益于使用合生剂。然而，现有试验的结果仍存在争议。因此，本荟萃分析评估了合生剂对 NAFLD 患者肝酶、血压、炎症和血脂谱的影响。
我们检索了 PubMed、Embase、Cochrane、Scopus 和 Web of Science 中关于合生剂补充治疗 NAFLD 患者的随机对照试验 (RCT)。
荟萃分析显示，合生剂补充治疗可显著改善肝酶 (AST，WMD：-9.12 IU/L；95%CI：-13.19 至 -5.05；ALT，WMD：-8.53 IU/L；95%CI：-15.07 至 -1.99；GGT，WMD：-10.42 IU/L；95%CI：-15.19 至 -5.65)、血脂谱 (TC，WMD：-7.74mg/dL；95%CI：-12.56 至 -2.92)、肥胖指数 (体重，WMD：-1.95kg；95%CI：-3.69 至 -0.22；WC，WMD：-1.40cm；95%CI：-2.71 至 -0.10)、收缩压 (SBP，WMD：-6.00mmHg；95%CI：-11.52 至 -0.49) 和炎症标志物 (CRP，WMD：-0.69mg/L；95%CI：-1.17 至 -0.21；TNF-α，WMD：-14.01pg/mL；95%CI：-21.81 至 -6.20)。
总的来说，合生剂补充治疗可改善 NAFLD 患者的肝酶、肥胖指数和炎症细胞因子。
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