Nephrology Department, Lai'an County People's Hospital, Chuzhou, 239000, China.
Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, No. 1800, Lihu Avenue, Binhu District, Wuxi, 214000, China.
BMC Gastroenterol. 2024 Aug 22;24(1):283. doi: 10.1186/s12876-024-03356-y.
There is a contradiction in the use of microbiota-therapies, including probiotics, prebiotics, and synbiotics, to improve the condition of patients with nonalcoholic fatty liver disease (NAFLD). The aim of this review was to evaluate the effect of microbiota-therapy on liver injury, inflammation, and lipid levels in individuals with NAFLD.
Using Pubmed, Embase, Cochrane Library, and Web of Science databases were searched for articles on the use of prebiotic, probiotic, or synbiotic for the treatment of patients with NAFLD up to March 2024.
Thirty-four studies involving 12,682 individuals were included. Meta-analysis indicated that probiotic, prebiotic, and synbiotic supplementation significantly improved liver injury (hepatic fibrosis, SMD = -0.31; 95% CI: -0.53, -0.09; aspartate aminotransferase, SMD = -0.35; 95% CI: -0.55, -0.15; alanine aminotransferase, SMD = -0.48; 95% CI: -0.71, -0.25; alkaline phosphatase, SMD = -0.81; 95% CI: -1.55, -0.08), lipid profiles (triglycerides, SMD = -0.22; 95% CI: -0.43, -0.02), and inflammatory factors (high-density lipoprotein, SMD = -0.47; 95% CI: -0.88, -0.06; tumour necrosis factor alpha, SMD = -0.86 95% CI: -1.56, -0.56).
Overall, supplementation with probiotic, prebiotic, or synbiotic had a positive effect on reducing liver enzymes, lipid profiles, and inflammatory cytokines in patients with NAFLD.
在使用包括益生菌、益生元和合生菌在内的微生物疗法来改善非酒精性脂肪性肝病 (NAFLD) 患者的病情方面存在矛盾。本综述的目的是评估微生物疗法对 NAFLD 患者肝损伤、炎症和血脂水平的影响。
使用 Pubmed、Embase、Cochrane 图书馆和 Web of Science 数据库检索了截至 2024 年 3 月使用益生元、益生菌或合生菌治疗 NAFLD 患者的文章。
共纳入 34 项涉及 12682 人的研究。Meta 分析表明，益生菌、益生元和合生菌补充剂可显著改善肝损伤（肝纤维化，SMD = -0.31；95%CI：-0.53，-0.09；天冬氨酸氨基转移酶，SMD = -0.35；95%CI：-0.55，-0.15；丙氨酸氨基转移酶，SMD = -0.48；95%CI：-0.71，-0.25；碱性磷酸酶，SMD = -0.81；95%CI：-1.55，-0.08）、血脂谱（甘油三酯，SMD = -0.22；95%CI：-0.43，-0.02）和炎症因子（高密度脂蛋白，SMD = -0.47；95%CI：-0.88，-0.06；肿瘤坏死因子-α，SMD = -0.86；95%CI：-1.56，-0.56）。
总的来说，补充益生菌、益生元和合生菌对降低 NAFLD 患者的肝酶、血脂谱和炎症细胞因子有积极作用。
