Dipartimento di Sicurezza e Bioetica, Sezione Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy.
UOC Malattie Infettive, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Travel Med Infect Dis. 2024 Nov-Dec;62:102757. doi: 10.1016/j.tmaid.2024.102757. Epub 2024 Sep 4.
High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG anti-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.
From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic. IgG against MPXV have been assessed on stored cryopreserved samples with an ELISA. Only people with no previous reported vaccine against smallpox or mpox nor previous clinical manifestations consistent with a mpox diagnosis were included.
285 PLWH were included. Twenty-one participants tested positive for IgG anti MPXV (7.37 %, 95 % CI 4.62-11.0). Seropositivity was predominant in male (15/285, 71.4) with a small fraction of female (6/285,28.6 %) and PWID (1/285,4.8 %).
Our findings suggest the possibility of an asymptomatic course of the mpox infection even in populations beyond traditional high-risk groups.
高发病率的猴痘表明无症状个体可能有助于病毒传播。我们进行这项研究是为了评估无症状 HIV 感染者队列中 IgG 抗 MPXV 的血清流行率，分析无症状感染现象的规模。
从 2022 年 10 月到 2023 年 3 月，我们连续收集了在我们诊所就诊的 HIV 感染者的血清样本。使用 ELISA 对储存的冷冻保存样本进行了 IgG 抗 MPXV 的评估。仅包括以前没有报告接种过天花或猴痘疫苗且以前的临床表现与猴痘诊断不符的人。
共纳入 285 名 HIV 感染者。21 名参与者 IgG 抗 MPXV 检测呈阳性（7.37%，95%CI 4.62-11.0）。血清阳性主要见于男性（285 名中的 15 名，71.4%），女性（285 名中的 6 名，28.6%）和 PWID（285 名中的 1 名，4.8%）比例较小。
我们的发现表明，即使在传统高危人群之外的人群中，也可能存在无症状猴痘感染的可能性。
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