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肝片吸虫和巨片吸虫中血型P1活性的检测(作者译)

[Detection of blood group P1 activity in F. hepatica and F. gigantica (author's transl)].

作者信息

Ben-Ismail R, Carme B, Gentilini M

出版信息

Pathol Biol (Paris). 1979 Oct;27(8):487-9.

PMID:392420
Abstract

Four lyophilizated liver flüke antigens and one of hydatid fluid were examined for the presence of blood group like antigens P1, A, B, M and N by an hemagglutination inhibition test with hyperimmune and natural hemagglutinating sera. P1 or P1-like substance was found in the extracts of "Fasciola hepatica" and "F. gigantica" in a lower concentration than in echinoccocal fluid. This presence may explain the occurrence of anti-P1 antibodies in patients infected with liver flüke and belonging to the P2 blood group. However biochemical studies will be necessary to determine if the P1 activity is due to the blood group P1 substance of the red cell itself or due to a P1 like substance.

摘要

通过用超免疫血清和天然血凝血清进行血凝抑制试验,检测了四种冻干肝吸虫抗原和一种棘球蚴液,以确定是否存在类血型抗原P1、A、B、M和N。在肝片吸虫和巨片吸虫的提取物中发现了P1或类P1物质,其浓度低于棘球蚴液中的浓度。这种存在可能解释了感染肝吸虫且属于P2血型的患者中抗P1抗体的出现。然而,需要进行生化研究以确定P1活性是由于红细胞本身的血型P1物质还是由于类P1物质。

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