Tribouley J, Tribouley-Duret J, Apriou M
Pathol Biol (Paris). 1979 Oct;27(8):491-2.
Significant resistance to Schistosoma mansoni appears in mice two weeks after treatment with BCG. The state of nonspecific resistance is considerably increased if the injection of BCG two weeks prior to the infestation test is carried out using mice who have already received BCG. Thus, BCG innoculation in an organism presentized to the bacillus antigens increases immunostimulation. According to these results, during primoinnoculation with BCG, immunostimulation is not significant before this second week, that is, the time necessary for a state of hypersensitivity to appear. Nevertheless, it should be noted that weak yet detectable immunostimulation can be observed before the 14th day following a BCG primoinfection. Thus, the possible role of other mechanisms should be considered.
用卡介苗治疗后两周，小鼠对曼氏血吸虫出现显著抗性。如果在感染测试前两周给已经接种过卡介苗的小鼠注射卡介苗，非特异性抗性状态会显著增强。因此，在对该杆菌抗原已有接触的机体中接种卡介苗会增强免疫刺激。根据这些结果，在初次接种卡介苗时，在第二周之前免疫刺激并不显著，即出现超敏反应所需的时间。然而，应该注意的是，在卡介苗初次感染后的第14天之前可以观察到微弱但可检测到的免疫刺激。因此，应该考虑其他机制的可能作用。
