Faculty of Medicine, Postgraduate Program in Medical Sciences, Fluminense Federal University, Rua Ataíde Parreiras, 100, Bairro de Fátima, Niterói, RJ 24070-090, Brazil; Department of Obstetrics and Gynecology, Rio de Janeiro Trophoblastic Disease Center, Maternity School of Rio de Janeiro Federal University, Rua Laranjeiras, 180, Laranjeiras, Rio de Janeiro, RJ 22240-003, Brazil; Postgraduate Program in Applied Health Sciences, Vassouras University, Av. Expedicionário Osvaldo de Almeida Ramos, 250, Bloco 03, 2 andar, Centro, Vassouras, RJ 27700-000, Brazil.
Faculty of Medicine, Postgraduate Program in Medical Sciences, Fluminense Federal University, Rua Ataíde Parreiras, 100, Bairro de Fátima, Niterói, RJ 24070-090, Brazil.
Hematol Oncol Clin North Am. 2024 Dec;38(6):1149-1159. doi: 10.1016/j.hoc.2024.07.001. Epub 2024 Sep 5.
Complete and partial molar pregnancies arise from abnormal fertilization with marked proliferation of syncytiotrophoblasts. Earlier diagnosis has reduced the frequency of severe medical complications at presentation; however, the risk of progression to gestational trophoblastic neoplasia (GTN) has remained unchanged. Initial assessment should include serum hCG measurement after physical examination, laboratory testing for organ dysfunction, and Doppler ultrasound. Following uterine evacuation, pathologic assessment can distinguish complete from partial moles or non-molar gestations. Close surveillance is essential for the timely diagnosis of GTN. Cure rates and subsequent obstetrics outcomes are excellent, but all patients should be referred for psychologic support and expert level care.
完全性和部分性葡萄胎是由于异常受精导致合体滋养细胞明显增生引起的。早期诊断降低了就诊时严重医疗并发症的发生频率；然而，进展为妊娠滋养细胞肿瘤（GTN）的风险仍然不变。初始评估应包括体格检查后血清 hCG 测量、器官功能障碍的实验室检查和多普勒超声检查。子宫排空后，病理评估可区分完全性和部分性葡萄胎或非葡萄胎妊娠。密切监测对于及时诊断 GTN 至关重要。治愈率和后续产科结局都非常好，但所有患者都应转介接受心理支持和专家级护理。
