Department of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA.
Cornell University, Ithaca, NY, USA.
Results Probl Cell Differ. 2024;73:301-326. doi: 10.1007/978-3-031-62036-2_13.
Cell-to-cell interactions are essential for proper development, homeostasis, and complex syncytia/organ formation and function. Intercellular communication are mediated by multiple mechanisms including soluble mediators, adhesion molecules and specific mechanisms of cell to cell communication such as Gap junctions (GJ), tunneling nanotubes (TNT), and exosomes. Only recently, has been discovered that TNTs and exosomes enable the exchange of large signaling molecules, RNA, viral products, antigens, and organelles opening new avenues of research and therapeutic approaches. The focus of this review is to summarize these recent findings in physiologic and pathologic conditions.
细胞间相互作用对于正常发育、内稳态以及复杂的合胞体/器官的形成和功能至关重要。细胞间通讯通过多种机制介导，包括可溶性介质、黏附分子以及细胞间通讯的特定机制，如间隙连接 (GJ)、隧道纳米管 (TNT) 和外泌体。直到最近，人们才发现 TNT 和外泌体能够交换大信号分子、RNA、病毒产物、抗原和细胞器，为研究和治疗方法开辟了新途径。本综述的重点是总结这些在生理和病理条件下的最新发现。
