Department of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Department of Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ann Neurol. 2024 Dec;96(6):1086-1091. doi: 10.1002/ana.27066. Epub 2024 Sep 7.
Slowly expanding lesions (SELs) in adults with multiple sclerosis (MS) indicate a progressive pathological process. Whether SELs are present in pediatric-onset MS (POMS) or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unknown. We studied 19 children with POMS and 14 with MOGAD (median age 14.3 and 9.4 years, respectively) recruited to the Canadian Pediatric Demyelinating Disease Study with: (1) ≥3 research scans 12 months apart; and (2) ≥1 T2-lesions on the earliest scan. A total of 70 SELs from 16 POMS participants and 1 SEL in the MOGAD group were detected. SELs are an early feature of POMS and essentially not a feature of MOGAD. ANN NEUROL 2024;96:1086-1091.
在多发性硬化症（MS）患者中，缓慢扩大的病灶（SELs）表明存在进行性病理过程。小儿发病型多发性硬化症（POMS）或髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）中是否存在 SELs 尚不清楚。我们研究了 19 名 POMS 患儿和 14 名 MOGAD 患儿（中位年龄分别为 14.3 岁和 9.4 岁），他们均入组了加拿大儿科脱髓鞘疾病研究：（1）≥3 次研究扫描，间隔 12 个月；（2）最早扫描时至少有 1 个 T2 病灶。在 16 名 POMS 参与者中发现了 70 个 SELs，在 MOGAD 组中发现了 1 个 SEL。SELs 是 POMS 的早期特征，而不是 MOGAD 的特征。神经病学年鉴 2024；96：1086-1091。
