School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Histopathology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Virchows Arch. 2024 Nov;485(5):879-888. doi: 10.1007/s00428-024-03924-3. Epub 2024 Sep 7.
The pathological assessment of cystectomy specimens is important for accurate prognostic information and to inform adjuvant therapy decisions. However, there is limited evidence regarding the best approach to fixation, dissection, block selection and microscopic assessment of cystectomies. We report the results of an international survey of 212 pathologists and their approach to cystectomy pathology. There is variation at all stages of the specimen journey including in fixation and dissection techniques, and in the approach to evaluating residual tumour. This is particularly evident in the post-neoadjuvant chemotherapy setting where there is variable use of response scoring systems and differing approaches to sampling. We also find variation in the use of digital and molecular pathology in cystectomy specimens. Finally, we have suggested areas for future research in cystectomy pathological assessment.
膀胱切除术标本的病理学评估对于准确的预后信息和辅助治疗决策非常重要。然而，关于膀胱切除术的最佳固定、解剖、切块选择和显微镜评估方法的证据有限。我们报告了对 212 名病理学家及其膀胱切除术病理学方法的国际调查结果。在标本处理的所有阶段都存在差异，包括固定和解剖技术，以及评估残留肿瘤的方法。在新辅助化疗后，这种差异尤其明显，因为使用的反应评分系统不同，采样方法也不同。我们还发现膀胱切除术标本中数字病理学和分子病理学的使用存在差异。最后，我们提出了未来在膀胱切除术病理评估方面的研究领域。
