Dhiman Ruby, Bazad Nancy, Mukherjee Riya, Leal Elcio, Ahmad Saheem, Kaur Kirtanjot, Raj V Samuel, Chang Chung-Ming, Pandey Ramendra Pati
Centre for Drug Design Discovery and Development (C4D), SRM University, Delhi-NCR, Rajiv Gandhi Education City, Sonepat, Haryana, India.
School of Health Sciences and Technology (SOHST), UPES, Dehradun, Uttarakhand, 248007, India.
Discov Nano. 2024 Sep 7;19(1):143. doi: 10.1186/s11671-024-04086-6.
Breast cancer (BC) remains a leading cause of morbidity and mortality among women worldwide, with triple-negative breast cancer (TNBC) posing significant treatment challenges due to its aggressive phenotype and resistance to conventional therapies. Recent advancements in nanocarrier technology offer promising solutions for enhancing drug delivery, improving bioavailability, and increasing drug accumulation at tumor sites through targeted approaches. This review delves into the latest innovations in BC detection and treatment, highlighting the role of nanocarriers like polymeric micelles, liposomes, and magnetic nanoparticles in overcoming the limitations of traditional therapies. Additionally, the manuscript discusses the integration of cutting-edge diagnostic tools, such as multiplex PCR-Nested Next-Generation Sequencing (mPCR-NGS) and blood-based biomarkers, which are revolutionizing early detection and molecular profiling of BC. The convergence of these technologies not only enhances therapeutic outcomes but also paves the way for personalized medicine in BC management. This comprehensive review underscores the potential of nanocarriers in transforming BC treatment and emphasizes the critical importance of early detection in improving patient prognosis.
乳腺癌（BC）仍然是全球女性发病和死亡的主要原因，三阴性乳腺癌（TNBC）因其侵袭性表型和对传统疗法的耐药性而带来了重大的治疗挑战。纳米载体技术的最新进展为通过靶向方法增强药物递送、提高生物利用度以及增加药物在肿瘤部位的蓄积提供了有前景的解决方案。这篇综述深入探讨了乳腺癌检测和治疗的最新创新，强调了聚合物胶束、脂质体和磁性纳米颗粒等纳米载体在克服传统疗法局限性方面的作用。此外，该文稿还讨论了前沿诊断工具的整合，如多重PCR-巢式下一代测序（mPCR-NGS）和基于血液的生物标志物，这些正在彻底改变乳腺癌的早期检测和分子分析。这些技术的融合不仅提高了治疗效果，也为乳腺癌管理中的个性化医疗铺平了道路。这篇全面的综述强调了纳米载体在改变乳腺癌治疗方面的潜力，并强调了早期检测对改善患者预后的至关重要性。
