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单壁碳纳米管共轭番泻叶提取物对乳腺癌细胞的影响：一种潜在的凋亡治疗策略。

Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy.

作者信息

Behairy Sabreen Mohammed, Al-Maaqar Saleh Mohammed, Al-Shaeri Majed Ahmed

机构信息

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Environmental Protection & Sustainability Research Group, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Open Life Sci. 2024 Dec 31;19(1):20220994. doi: 10.1515/biol-2022-0994. eCollection 2024.

DOI:10.1515/biol-2022-0994
PMID:39759104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11699557/
Abstract

Breast cancer (BC) has a prevalence rate of 21.8% among Saudi women and ranks as the third leading cause of death in Western nations. Nanotechnology offers innovative methods for targeted BC therapy, and this study explores the use of single-walled carbon nanotubes (SWCNTs) for delivering the senna leaf extract. The study evaluated the effects of increasing dosages of senna leaf extract conjugated to SWCNTs on MCF-7 cells. Cell viability was assessed using the MTT assay, while Giemsa staining revealed morphological changes. Additionally, the comet assay and agarose gel electrophoresis were employed to evaluate the pro-apoptotic potential. The potential of mitochondrial membrane and the production of reactive oxygen species (ROS) were investigated using the JC-1 dye. The results indicated that treated cells exhibited apoptotic characteristics, including elevated ROS levels and decreased mitochondrial membrane potential. In summary, the application of nanotechnology to deliver the senna leaf extract shows promise as a herbal treatment for BC, suggesting a potential breakthrough in combating this widespread and deadly disease.

摘要

乳腺癌（BC）在沙特女性中的患病率为21.8%，在西方国家是第三大死因。纳米技术为靶向性乳腺癌治疗提供了创新方法，本研究探索了使用单壁碳纳米管（SWCNT）来递送番泻叶提取物。该研究评估了与SWCNT偶联的番泻叶提取物剂量增加对MCF-7细胞的影响。使用MTT法评估细胞活力，而吉姆萨染色揭示了形态学变化。此外，采用彗星试验和琼脂糖凝胶电泳来评估促凋亡潜力。使用JC-1染料研究线粒体膜电位和活性氧（ROS）的产生。结果表明，处理后的细胞表现出凋亡特征，包括ROS水平升高和线粒体膜电位降低。总之，应用纳米技术递送番泻叶提取物显示出作为乳腺癌草药治疗方法的前景，表明在对抗这种广泛且致命的疾病方面可能取得突破。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/b9d566e9565c/j_biol-2022-0994-fig010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/e005577e441c/j_biol-2022-0994-fig001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/7c4d576850d5/j_biol-2022-0994-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/26ab6e32a9f5/j_biol-2022-0994-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/4f1725e92699/j_biol-2022-0994-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/94df6a022ffa/j_biol-2022-0994-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/e9a7b27c623d/j_biol-2022-0994-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/378982573418/j_biol-2022-0994-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/1a2e49101320/j_biol-2022-0994-fig009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/b9d566e9565c/j_biol-2022-0994-fig010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/e005577e441c/j_biol-2022-0994-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/0812734b9cb1/j_biol-2022-0994-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/7c4d576850d5/j_biol-2022-0994-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/26ab6e32a9f5/j_biol-2022-0994-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/4f1725e92699/j_biol-2022-0994-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/94df6a022ffa/j_biol-2022-0994-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/e9a7b27c623d/j_biol-2022-0994-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/378982573418/j_biol-2022-0994-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/1a2e49101320/j_biol-2022-0994-fig009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cd/11699557/b9d566e9565c/j_biol-2022-0994-fig010.jpg

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