College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China.
Zhaotong Hospital of Chinese Traditional Medicine, Zhaotong 657000, People's Republic of China.
Int Immunopharmacol. 2024 Dec 5;142(Pt A):112996. doi: 10.1016/j.intimp.2024.112996. Epub 2024 Sep 6.
Atherosclerosis is marked with the accumulation of low-density lipoproteins and chronic inflammation. The anti-inflammatory therapies exert protective effects on atherosclerosis. Vasicine is a bioactive alkaloid with anti-inflammatory activity from a medicinal plant in Ayurveda and Unani. In this study, the effects of vasicine were evaluated on atherosclerosis in vivo and in vitro. The results showed that vasicine alleviated atherosclerotic lesions and regulated the lipid synthesis by reducing the levels of TC, TG, LDL-C and inhibiting the expresses of scavenger receptors (SR-A, CD36 and LOX-1) to inhibit foam cell formations. And vasicine decreased the levels of IL-1β, IL-6, MCP-1, and TNF-α to modulate inflammatory response. Besides, vasicine downregulated MAPK and PI3K/AKT/mTOR pathway to activated autophagy, which inhibited the procession of atherosclerosis.
动脉粥样硬化的特征是低密度脂蛋白的积累和慢性炎症。抗炎治疗对动脉粥样硬化具有保护作用。蝙蝠葛碱是一种具有抗炎活性的生物活性生物碱，来自印度阿育吠陀和尤纳尼医学中的药用植物。在这项研究中，评估了蝙蝠葛碱对体内和体外动脉粥样硬化的作用。结果表明，蝙蝠葛碱通过降低 TC、TG、LDL-C 的水平并抑制清道夫受体（SR-A、CD36 和 LOX-1）的表达来抑制泡沫细胞形成，从而减轻动脉粥样硬化病变并调节脂质合成。而且，蝙蝠葛碱降低了 IL-1β、IL-6、MCP-1 和 TNF-α 的水平，从而调节炎症反应。此外，蝙蝠葛碱下调 MAPK 和 PI3K/AKT/mTOR 通路以激活自噬，从而抑制动脉粥样硬化的进程。
